Osteoarthritis is a common joint disease for which there are currently no disease-modifying
drugs available. Degradation of the cartilage extracellular matrix is a central feature of the …

The goal is to provide an extensive review of the physiologic role of thrombomodulin (TM) in
maintaining vascular homeostasis, with a focus on its anti-inflammatory properties. Data …

Objectives To investigate the regulation of sclerostin (SOST) in osteoarthritis (OA) and its
potential effects on articular cartilage degradation. Methods SOST and other Wnt-β-catenin …

Objective To explore the involvement of protease‐activated receptor 1 (PAR‐1) and PAR‐2
in the pathologic processes of osteoarthritis (OA) and to identify the cells/tissues primarily …

Several recent in vitro investigations and experimental studies performed in animal models
of osteoarthritis (OA) sustained the previously held view that interleukin (IL)-1 or tumour …

In this study we analyzed the chondrogenic potential of subpopulations of mesenchymal
stem cells (MSCs) derived from human synovial membranes enriched for CD73, CD106 …

Primary osteoarthritis (OA) is a musculoskeletal disorder of unknown etiology. OA is
characterized by an imbalance between anabolism and catabolism in, and altered …

Objective Levels of activated protein C (APC) are elevated in the synovial fluid of patients
with osteoarthritis (OA), and increased APC levels are correlated with the levels of active …

Articular cartilage is a uniquely ordered tissue that is designed to resist compression and
redistribute load, but is poorly equipped for self-repair. The chondrocyte is the only resident …

MicroRNAs (miRNAs) are a family of non-coding RNAs that play an important role in human
diseases, including osteoarthritis (OA). The objective of this study was to investigate the …