Pioneer transcription factors have the intrinsic biochemical ability to scan partial DNA
sequence motifs that are exposed on the surface of a nucleosome and thus access silent …

In the few years since its initial application, massively parallel cDNA sequencing, or RNA-
seq, has allowed many advances in the characterization and quantification of …

The modulation of DNA-protein interactions by methylation of protein-binding sites in DNA
and the occurrence in genomic imprinting, X chromosome inactivation, and fragile X …

Precise mapping of DNA methylation patterns in CpG islands has become essential for
understanding diverse biological processes such as the regulation of imprinted genes, X …

The past few years have seen an explosion of interest in the epigenetics of cancer. This has
been a consequence of both the exciting coalescence of the chromatin and DNA …

An understanding of DNA methylation and its potential role in gene control during
development, aging and cancer has been hampered by a lack of sensitive methods which …

The first-order rate constants for the hydrolysis of a phosphodiester bond under
physiological conditions have been estimated to be 6 X 10-9 and 6 X 10-10 min-1 for single …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

SINCE ITS FIRST recognition in 1948, the fifth base of human DNA, 5-methylcytosine (5-mC)
has generated much interest and considerable controversy during attempts to understand its …

Nucleic-acid binding proteins constitute nearly one-fourth of all functionally annotated
human genes. Genome-wide analysis of protein–nucleic acid contacts has not yet been …