There is now considerable and increasing evidence for a causal role for aberrant activity of
the Ras superfamily of small GTPases in human cancers. These GTPases function as GDP …

When migrating away from a primary tumour, cancer cells interact with and remodel the
extracellular matrix (ECM). Matrix metalloproteinases (MMPs), and in particular the …

Phosphatidic acid (PA) is a critical phospholipid constituent in eukaryotic cell membranes,
which accounts for 1À4% of the total lipid. 1 This lipophilic glycerophospholipid has a …

Small G proteins play a central role in the organization of the secretory and endocytic
pathways. The majority of such small G proteins are members of the Rab family, which are …

Cell-death and-survival decisions are critically controlled by intracellular Ca 2+ homeostasis
and dynamics at the level of the endoplasmic reticulum (ER). Inositol 1, 4, 5-trisphosphate …

Purpose: To carry out an integrative profile of human pancreatic ductal adenocarcinoma
(PDAC) to identify prognosis-significant genes and their related pathways. Experimental …

Epidermal growth factor (EGF) receptor (EGFR) signalling is implicated in tumour invasion
and metastasis,. However, whether there are EGFR signalling pathways specifically used for …

The Arf small G proteins regulate protein and lipid trafficking in eukaryotic cells through a
regulated cycle of GTP binding and hydrolysis. In their GTP-bound form, Arf proteins recruit a …

Tumors are tissue‐specific diseases, and their mechanisms of invasion and metastasis are
highly diverse. In breast cancer, biomarkers that specifically correlate with the invasive …

Arf and Rho GTP-binding proteins coordinately regulate membrane dynamics and
cytoskeletal rearrangements. The Cdc42/Rac guanine nucleotide exchange factor PIX and …