Environmental factors in declining human fertility
NE Skakkebæk, R Lindahl-Jacobsen… - Nature Reviews …, 2022 - nature.com
A severe decline in child births has occurred over the past half century, which will lead to
considerable population declines, particularly in industrialized regions. A crucial question is …
considerable population declines, particularly in industrialized regions. A crucial question is …
Menopause transition and cardiovascular disease risk: implications for timing of early prevention: a scientific statement from the American Heart Association
SR El Khoudary, B Aggarwal, TM Beckie, HN Hodis… - Circulation, 2020 - Am Heart Assoc
Cardiovascular disease (CVD) is the leading cause of death in women, who have a notable
increase in the risk for this disease after menopause and typically develop coronary heart …
increase in the risk for this disease after menopause and typically develop coronary heart …
Key steps for effective breast cancer prevention
Despite decades of laboratory, epidemiological and clinical research, breast cancer
incidence continues to rise. Breast cancer remains the leading cancer-related cause of …
incidence continues to rise. Breast cancer remains the leading cancer-related cause of …
Genetic insights into biological mechanisms governing human ovarian ageing
Reproductive longevity is essential for fertility and influences healthy ageing in women,, but
insights into its underlying biological mechanisms and treatments to preserve it are limited …
insights into its underlying biological mechanisms and treatments to preserve it are limited …
Deconstructing a syndrome: genomic insights into PCOS causal mechanisms and classification
Polycystic ovary syndrome (PCOS) is among the most common disorders in women of
reproductive age, affecting up to 15% worldwide, depending on the diagnostic criteria …
reproductive age, affecting up to 15% worldwide, depending on the diagnostic criteria …
[HTML][HTML] Landscape of pathogenic mutations in premature ovarian insufficiency
H Ke, S Tang, T Guo, D Hou, X Jiao, S Li, W Luo… - Nature Medicine, 2023 - nature.com
Premature ovarian insufficiency (POI) is a major cause of female infertility due to early loss of
ovarian function. POI is a heterogeneous condition, and its molecular etiology is unclear. To …
ovarian function. POI is a heterogeneous condition, and its molecular etiology is unclear. To …
[HTML][HTML] Premature ovarian insufficiency: past, present, and future
Premature ovarian insufficiency (POI) is the loss of normal ovarian function before the age of
40 years, a condition that affects approximately 1% of women under 40 years old and 0.1 …
40 years, a condition that affects approximately 1% of women under 40 years old and 0.1 …
[HTML][HTML] The Rotterdam Study: 2018 update on objectives, design and main results
MA Ikram, GGO Brusselle, SD Murad… - European journal of …, 2017 - Springer
Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …
Association of age at onset of menopause and time since onset of menopause with cardiovascular outcomes, intermediate vascular traits, and all-cause mortality: a …
Importance As many as 10% of women experience natural menopause by the age of 45
years. If confirmed, an increased risk of cardiovascular disease (CVD) and all-cause …
years. If confirmed, an increased risk of cardiovascular disease (CVD) and all-cause …
New genetic loci link adipose and insulin biology to body fat distribution
D Shungin, TW Winkler, DC Croteau-Chonka… - Nature, 2015 - nature.com
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …
outcomes, independent of overall adiposity. To increase our understanding of the genetic …