Inflammation and atherosclerosis: signaling pathways and therapeutic intervention

P Kong, ZY Cui, XF Huang, DD Zhang… - Signal transduction and …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and
nontraditional risk factors. Genome-wide association combined with clonal lineage tracing …

Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?

SE Engelen, AJB Robinson, YX Zurke… - Nature Reviews …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …

Heterogeneity of immune cells in human atherosclerosis revealed by scRNA-Seq

J Vallejo, C Cochain, A Zernecke… - Cardiovascular …, 2021 - academic.oup.com
Immune cells in atherosclerosis include T, B, natural killer (NK) and NKT cells,
macrophages, monocytes, dendritic cells (DCs), neutrophils, and mast cells. Advances in …

Inflammation: A new look at an old problem

E Gusev, Y Zhuravleva - International Journal of Molecular Sciences, 2022 - mdpi.com
Pro-inflammatory stress is inherent in any cells that are subject to damage or threat of
damage. It is defined by a number of universal components, including oxidative stress …

Porphyromonas gingivalis regulates atherosclerosis through an immune pathway

Q Ruan, P Guan, W Qi, J Li, M Xi, L Xiao… - Frontiers in …, 2023 - frontiersin.org
Atherosclerosis (AS) is a chronic inflammatory disease, involving a pathological process of
endothelial dysfunction, lipid deposition, plaque rupture, and arterial occlusion, and is one of …

Atherosclerosis With Immune Checkpoint Inhibitor Therapy: Evidence, Diagnosis, and Management: JACC: CardioOncology State-of-the-Art Review

GA Suero-Abreu, MV Zanni, TG Neilan - Cardio Oncology, 2022 - jacc.org
As the clinical applications of immune checkpoint inhibitors (ICIs) expand, our knowledge of
the potential adverse effects of these drugs continues to broaden. Emerging evidence …

The emerging role of Th1 cells in atherosclerosis and its implications for therapy

J Chen, X Xiang, L Nie, X Guo, F Zhang… - Frontiers in …, 2023 - frontiersin.org
Atherosclerosis is a chronic progressive inflammatory disease of the large and medium-
sized artery walls. The molecular mechanisms regulating the onset and progression of …

T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice

V Bazioti, AM La Rose, S Maassen, F Bianchi… - Nature …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory disease driven by hypercholesterolemia. During
aging, T cells accumulate cholesterol, potentially affecting inflammation. However, the effect …

T cells in atherosclerosis: key players in the pathogenesis of vascular disease

H Hinkley, DA Counts, E VonCanon, M Lacy - Cells, 2023 - mdpi.com
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipid-
rich plaques within arterial walls. T cells play a pivotal role in the pathogenesis of …

Molecular fingerprints of cardiovascular toxicities of immune checkpoint inhibitors

TG Gergely, ZD Drobni, NV Sayour… - Basic Research in …, 2024 - Springer
Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy by unleashing the
power of the immune system against malignant cells. However, their use is associated with a …