Open science in precision medicine for neurodegenerative diseases Skip to main content Thank
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More than 50% of drug programs fail due to lack of efficacy. While the reasons are manifold,
the root causes are simple. First, modulating the target has no effect on the disease. Second …

Hypertension remains a leading cause of cardiovascular and kidney diseases. Failure to
control blood pressure with≥ 3 medications or control requiring≥ 4 medications is …

The past year has seen a huge increase in the genes implicated for atopic dermatitis and in
the use of genetics to explore causal relationships. The latter requires caution in …

The relationship between sleep disorders and neurodegeneration is complex and multi-
faceted. Using over one million electronic health records (EHRs) from Wales, UK, and …

Background: Schizophrenia genome-wide association studies (GWASes) have identified>
250 significant loci and prioritized> 100 disease-related genes. However, gene prioritization …

Fine-mapping and gene-prioritisation techniques applied to the latest Genome-Wide
Association Study (GWAS) results have prioritised hundreds of genes as causally …

90% of therapeutic programs that enter clinical trials ultimately fail. Human genetic variation
provides a set of" natural experiments" that can inform successful strategies for therapeutic …

Despite widespread use of drugs targeting traditional cardiovascular risk factors such as
lipids and blood pressure, a high burden of coronary heart disease (CHD) remains, hence …

We argue that biological risk for novel inhibitory drug targets can be minimized, almost
eliminated, by a computational analysis of the healthcare records and DNA sequences in …