Plasmacytoid dendritic cells (pDCs) are a unique sentinel cell type that can detect pathogen-
derived nucleic acids and respond with rapid and massive production of type I interferon …

As we age, the innate immune system becomes dysregulated and is characterized by
persistent inflammatory responses that involve multiple immune and non-immune cell types …

Older organs represent an untapped potential to close the gap between demand and supply
in organ transplantation but are associated with age-specific responses to injury and …

The immune systems of post-pubescent males and females differ significantly with profound
consequences to health and disease. In many cases, sex-specific differences in the immune …

The concept of immunosenescence reflects age-related changes in immune responses,
both cellular and serological, affecting the process of generating specific responses to …

Human aging is characterized by both physical and physiological frailty that profoundly
affects the immune system. In this context aging is associated with declines in adaptive and …

Given the" inborn" nature of the innate immune system, it is surprising to find that innate
immune function does in fact change with age. Similar patterns of distinct Toll-like-receptor …

Autoimmune connective tissue diseases arise in a stepwise fashion from asymptomatic
preclinical autoimmunity. Type I interferons have a crucial role in the progression to …

The immune systems of men and women differ in significant ways, especially after puberty.
In particular, females are generally more prone to autoimmunity, but experience lower rates …

The innate immune system is composed of a network of cells including neutrophils, NK and
NKT cells, monocytes/macrophages, and dendritic cells that mediate the earliest interactions …