The renaissance of α‐methylene‐γ‐butyrolactones: new synthetic approaches

RRA Kitson, A Millemaggi… - Angewandte Chemie …, 2009 - Wiley Online Library
The amount of research activity concerning α‐methylene‐γ‐butyrolactones and α‐alkylidene‐
γ‐butyrolactones has increased dramatically in recent years. This Review summarizes the …

Recent advances in the synthesis of α‐alkylidene‐substituted δ‐lactones, γ‐lactams and δ‐lactams

A Albrecht, Ł Albrecht, T Janecki - European Journal of Organic …, 2011 - Wiley Online Library
Abstract α‐Alkylidene‐substituted δ‐lactones and corresponding γ‐and δ‐lactams constitute
important classes of natural compounds that display diverse biological activities. This review …

Total Synthesis of (±)‐Phyllantidine: Development and Mechanistic Evaluation of a Ring Expansion for Installation of Embedded Nitrogen‐Oxygen Bonds

KM Lambert, JB Cox, L Liu, AC Jackson… - Angewandte Chemie …, 2020 - Wiley Online Library
The development of a concise total synthesis of (±)‐phyllantidine (1), a member of the
securinega family of alkaloids containing an unusual oxazabicyclo [3.3. 1] nonane core, is …

Die Renaissance der α‐Methylen‐γ‐butyrolactone: neue Syntheseansätze

RRA Kitson, A Millemaggi, RJK Taylor - Angewandte Chemie, 2009 - Wiley Online Library
Seit einigen Jahren erlebt die Forschung an α‐Methylen‐γ‐butyrolactonen einen enormen
Aufschwung. Diese Übersicht beschreibt die Strukturen, die biologische Aktivität und die …

Synthesis and Antimicrobial Activity of the Pathogenic E. coli Strains of p-Quinols: Additive Effects of Copper-Catalyzed Addition of Aryl Boronic Acid to …

D Koszelewski, P Kowalczyk… - International Journal of …, 2023 - mdpi.com
A mild and efficient protocol for the synthesis of p-quinols under aqueous conditions was
developed. The pivotal role of additives in the copper-catalyzed addition of aryl boronic and …

Regio-and stereoselective selenium dioxide allylic oxidation of (E)-dialkyl alkylidenesuccinates to (Z)-allylic alcohols: Synthesis of natural and unnatural butenolides

RM Patel, VG Puranik, NP Argade - Organic & Biomolecular Chemistry, 2011 - pubs.rsc.org
The first SeO2 induced (Z)-selective allylic alcohol formation of dialkyl alkylidenesuccinates
has been demonstrated to accomplish one-step syntheses of several essential butenolides …

Pd (II)-catalyzed synthesis of alkylidene phthalides via a decarbonylative annulation reaction

S Borthakur, S Baruah, B Sarma, S Gogoi - Organic letters, 2019 - ACS Publications
An unprecedented Pd (II)-catalyzed decarbonylative C–H/C–C activation and annulation
reaction, which proceeds via intramolecular cyclization, is reported. This reaction of …

Rapid Access to 2‐Methylene Tetrahydrofurans and γ‐Lactones: A Tandem Four‐Step Process

R Liang, K Chen, Q Zhang, J Zhang… - Angewandte Chemie …, 2016 - Wiley Online Library
A one‐pot tandem process involving hydrolysis, Knoevenagel condensation, Michael
addition, and Conia‐ene (HKMC) reactions has been developed for the rapid synthesis of …

A One-Pot C–H Insertion/Olefination Sequence for the Formation of α-Alkylidene-γ-butyrolactones

MG Lloyd, RJK Taylor, WP Unsworth - Organic Letters, 2014 - ACS Publications
A one-pot C–H insertion/olefination sequence for the conversion of α-diazo-α-
(dialkoxyphosphoryl) acetates into α-alkylidene-γ-butyrolactones is reported. The key C–H …

α-Alkylidene-γ-butyrolactone synthesis via one-pot C–H insertion/olefination: substrate scope and the total synthesis of (±)-cedarmycins A and B

MG Lloyd, M D'Acunto, RJK Taylor, WP Unsworth - Tetrahedron, 2015 - Elsevier
A system for the synthesis of α-alkylidene-γ-butyrolactones via a one-pot C–H
insertion/olefination sequence is described. The process is based on the rhodium catalysed …