A cellular perspective on brain energy metabolism and functional imaging
PJ Magistretti, I Allaman - Neuron, 2015 - cell.com
The energy demands of the brain are high: they account for at least 20% of the body's
energy consumption. Evolutionary studies indicate that the emergence of higher cognitive …
energy consumption. Evolutionary studies indicate that the emergence of higher cognitive …
Metabolomics in the context of plant natural products research: From sample preparation to metabolite analysis
Plant-derived natural products have long been considered a valuable source of lead
compounds for drug development. Natural extracts are usually composed of hundreds to …
compounds for drug development. Natural extracts are usually composed of hundreds to …
Association of OPRM1 functional coding variant with opioid use disorder: a genome-wide association study
Importance With the current opioid crisis, it is important to improve understanding of the
biological mechanisms of opioid use disorder (OUD). Objectives To detect genetic risk …
biological mechanisms of opioid use disorder (OUD). Objectives To detect genetic risk …
Development of a comprehensive genotype-to-fitness map of adaptation-driving mutations in yeast
Adaptive evolution plays a large role in generating the phenotypic diversity observed in
nature, yet current methods are impractical for characterizing the molecular basis and fitness …
nature, yet current methods are impractical for characterizing the molecular basis and fitness …
Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes
KW Kelley, H Nakao-Inoue, AV Molofsky… - Nature …, 2018 - nature.com
It is widely assumed that cells must be physically isolated to study their molecular profiles.
However, intact tissue samples naturally exhibit variation in cellular composition, which …
However, intact tissue samples naturally exhibit variation in cellular composition, which …
Protocol: a fast, comprehensive and reproducible one-step extraction method for the rapid preparation of polar and semi-polar metabolites, lipids, proteins, starch and …
MA Salem, J Jüppner, K Bajdzienko, P Giavalisco - Plant Methods, 2016 - Springer
Background The elucidation of complex biological systems requires integration of multiple
molecular parameters. Accordingly, high throughput methods like transcriptomics …
molecular parameters. Accordingly, high throughput methods like transcriptomics …
[图书][B] How humans cooperate: Confronting the challenges of collective action
RE Blanton - 2016 - books.google.com
In How Humans Cooperate, Richard E. Blanton and Lane F. Fargher take a new approach to
investigating human cooperation, developed from the vantage point of an" anthropological …
investigating human cooperation, developed from the vantage point of an" anthropological …
Primate cell fusion disentangles gene regulatory divergence in neurodevelopment
Among primates, humans display a unique trajectory of development that is responsible for
the many traits specific to our species. However, the inaccessibility of primary human and …
the many traits specific to our species. However, the inaccessibility of primary human and …
Limits of ultra: towards an interdisciplinary understanding of ultra-endurance running performance
Ultra-endurance running (UER) poses extreme mental and physical challenges that present
many barriers to completion, let alone performance. Despite these challenges, participation …
many barriers to completion, let alone performance. Despite these challenges, participation …
Solid phase microextraction-based miniaturized probe and protocol for extraction of neurotransmitters from brains in vivo
Despite the importance of monitoring and correlating neurotransmitter concentrations in the
brain with observable behavior and brain areas in which they act, in vivo measurement of …
brain with observable behavior and brain areas in which they act, in vivo measurement of …