Dealing with dimensionality: the application of machine learning to multi-omics data

D Feldner-Busztin, P Firbas Nisantzis… - …, 2023 - academic.oup.com
Motivation Machine learning (ML) methods are motivated by the need to automate
information extraction from large datasets in order to support human users in data-driven …

Transformer architecture and attention mechanisms in genome data analysis: a comprehensive review

SR Choi, M Lee - Biology, 2023 - mdpi.com
Simple Summary The rapidly advancing field of deep learning, specifically transformer-
based architectures and attention mechanisms, has found substantial applicability in …

Unbiased curriculum learning enhanced global-local graph neural network for protein thermodynamic stability prediction

H Gong, Y Zhang, C Dong, Y Wang, G Chen… - …, 2023 - academic.oup.com
Motivation Proteins play crucial roles in biological processes, with their functions being
closely tied to thermodynamic stability. However, measuring stability changes upon point …

Diagnosis of glioblastoma multiforme progression via interpretable structure-constrained graph neural networks

X Song, J Li, X Qian - IEEE Transactions on Medical Imaging, 2022 - ieeexplore.ieee.org
Glioblastoma multiforme (GBM) is the most common type of brain tumors with high
recurrence and mortality rates. After chemotherapy treatment, GBM patients still show a high …

MHADTI: predicting drug–target interactions via multiview heterogeneous information network embedding with hierarchical attention mechanisms

Z Tian, X Peng, H Fang, W Zhang… - Briefings in …, 2022 - academic.oup.com
Motivation Discovering the drug–target interactions (DTIs) is a crucial step in drug
development such as the identification of drug side effects and drug repositioning. Since …

Orchestrating information across tissues via a novel multitask GAT framework to improve quantitative gene regulation relation modeling for survival analysis

M Duan, Y Wang, D Zhao, H Liu, G Zhang… - Briefings in …, 2023 - academic.oup.com
Survival analysis is critical to cancer prognosis estimation. High-throughput technologies
facilitate the increase in the dimension of genic features, but the number of clinical samples …

Multi-scale characterisation of homologous recombination deficiency in breast cancer

DH Jacobson, S Pan, J Fisher, M Secrier - Genome Medicine, 2023 - Springer
Background Homologous recombination is a robust, broadly error-free mechanism of double-
strand break repair, and deficiencies lead to PARP inhibitor sensitivity. Patients displaying …

A systematic review of graph neural network in healthcare-based applications: Recent advances, trends, and future directions

SG Paul, A Saha, MZ Hasan, SRH Noori… - IEEE …, 2024 - ieeexplore.ieee.org
Graph neural network (GNN) is a formidable deep learning framework that enables the
analysis and modeling of intricate relationships present in data structured as graphs. In …

Deep Learning‐Based Multiomics Data Integration Methods for Biomedical Application

Y Wen, L Zheng, D Leng, C Dai, J Lu… - Advanced Intelligent …, 2023 - Wiley Online Library
The innovation of high‐throughput technologies and medical radiomics allows biomedical
data to accumulate at an astonishing rate. Several promising deep learning (DL) methods …

TEMINET: A Co-Informative and Trustworthy Multi-Omics Integration Network for Diagnostic Prediction

H Luo, H Liang, H Liu, Z Fan, Y Wei, X Yao… - International Journal of …, 2024 - mdpi.com
Advancing the domain of biomedical investigation, integrated multi-omics data have shown
exceptional performance in elucidating complex human diseases. However, as the variety of …