Oral delivery of biomacromolecules by overcoming biological barriers in the gastrointestinal tract: an update

S Liu, X Wen, X Zhang, S Mao - Expert opinion on drug delivery, 2023 - Taylor & Francis
Introduction Biomacromolecules have proven to be an attractive choice for treating diseases
due to their properties of strong specificity, high efficiency, and low toxicity. Besides greatly …

Biodegradable polymeric insulin microneedles–a design and materials perspective review

M Starlin Chellathurai, S Mahmood… - Drug Delivery, 2024 - Taylor & Francis
Microneedle (MN) delivery devices are more accepted by people than regular traditional
needle injections (eg vaccination) due to their simplicity and adaptability. Thus, patients of …

Materials and structure of polysaccharide-based delivery carriers for oral insulin: A review

X Wang, H Sun, T Mu - Carbohydrate Polymers, 2024 - Elsevier
Diabetes mellitus is a chronic metabolic disease that affects> 500 million patients worldwide.
Subcutaneous injection of insulin is the most effective treatment at present. However, regular …

β-Glucan and fatty acid based mucoadhesive carrier for gastrointestinal tract specific local and sustained drug delivery

SV Esquivel, HN Bhatt, R Diwan, A Habib, WY Lee… - Biomolecules, 2023 - mdpi.com
The oral route is considered the most convenient route of drug administration for both
systemic and local delivery. Besides stability and transportation, another unmet but …

[HTML][HTML] Chinese herb pollen derived micromotors as active oral drug delivery system for gastric ulcer treatment

L Cai, C Zhao, X Cao, M Lu, N Li, Y Luo, Y Wang… - Bioactive Materials, 2024 - Elsevier
Considerable efforts have been devoted to treating gastric ulcers. Attempts in this field tend
to develop drug delivery systems with prolonged gastric retention time. Herein, we develop …

[HTML][HTML] Emerging frontiers in drug delivery with special focus on novel techniques for targeted therapies

L Yu, S Liu, S Jia, F Xu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
The management and treatment of disease are achieved via the use of pharmacologically
active substances or drugs. Drugs do not, however, have an intrinsic ability to be effective; …

Untethered shape-changing devices in the gastrointestinal tract

W Liu, SJ Choi, D George, L Li, Z Zhong… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Advances in microfabrication, automation, and computer engineering seek to
revolutionize small-scale devices and machines. Emerging trends in medicine point to smart …

Gastrointestinal Permeation Enhancers Beyond Sodium Caprate and SNAC‐What is Coming Next?

M Bohley, JC Leroux - Advanced Science, 2024 - Wiley Online Library
Oral peptide delivery is trending again. Among the possible reasons are the recent
approvals of two oral peptide formulations, which represent a huge stride in the field. For the …

More Than Metal–Organic Frameworks: Intestinal Villi‐Inspired Device as a Therapeutic Platform for Oral Enzyme Delivery

X Qi, K Liu, Q Chen, Y Deng - Advanced Functional Materials, 2024 - Wiley Online Library
Macromolecules are fragile when orally administered. An intestinal villi‐inspired metal–
organic frameworks (MOFs)‐based smart pill with multiple advantages is developed to offer …

Designing self-triggered micro/milli devices for gastrointestinal tract drug delivery

LJ Cai, Y Wang, Z Luo, J Wang, H Ren… - Expert Opinion on Drug …, 2023 - Taylor & Francis
Introduction Self-triggered micro-/milli-devices (STMDs), which are artificial devices capable
of responding to the surrounding environment and transferring external energy into kinetic …