Premature infants are exposed to increased generation of reactive oxygen species, and on
the other hand, they have a deficient antioxidant defense system. Oxidative insult is a salient …

Bronchopulmonary dysplasia (BPD) is the most common cause of morbidity and mortality in
preterm infants. A key histopathological feature of BPD is stunted late lung development …

This review summarizes the current knowledge on the physiological action of endogenous
and exogenous pulmonary surfactant, the role of different types of animal-derived and …

Background In preterm infants on moderately high ventilator support, the addition of
budesonide to surfactant lowered bronchopulmonary dysplasia (BPD) rates by 20% without …

Drug delivery using a surfactant vehicle has the potential to prevent systemic side effects by
delivering therapeutic agents directly to the respiratory system. The inherent chemical …

Although advances in the respiratory management of extremely preterm infants have led to
improvements in survival, this progress has not yet extended to a reduction in the incidence …

Mechanical ventilation with normal tidal volumes (VT) causes lung and systemic
inflammation in preterm sheep. Mechanical ventilation is associated with bronchopulmonary …

Pulmonary surfactant is a complex lipoprotein mixture secreted into the alveolar lumen by
type 2 pneumocytes, which is composed by tens of different lipids (approximately 90% of its …

Recent clinical trials have shown improvements in neonatal outcomes after intratracheal
administration of a combination of budesonide/surfactant (ITBS) in infants at risk of …

Background Initial trials of lung-targeted budesonide (0.25 mg/kg) in surfactant to prevent
bronchopulmonary dysplasia (BPD) in premature infants have shown benefit; however, the …