Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapy

R Du, C Huang, K Liu, X Li, Z Dong - Molecular cancer, 2021 - Springer
Aurora kinase A (AURKA) belongs to the family of serine/threonine kinases, whose
activation is necessary for cell division processes via regulation of mitosis. AURKA shows …

The role of hypoxia in glioblastoma invasion

AR Monteiro, R Hill, GJ Pilkington, PA Madureira - Cells, 2017 - mdpi.com
Glioblastoma multiforme (GBM), a grade IV astrocytoma, is the most common and deadly
type of primary malignant brain tumor, with a patient's median survival rate ranging from 15 …

[HTML][HTML] A non-proliferative role of pyrimidine metabolism in cancer

A Siddiqui, P Ceppi - Molecular metabolism, 2020 - Elsevier
Background Nucleotide metabolism is a critical pathway that generates purine and
pyrimidine molecules for DNA replication, RNA synthesis, and cellular bioenergetics …

Aurora kinase A, a synthetic lethal target for precision cancer medicine

PK Mou, EJ Yang, C Shi, G Ren, S Tao… - Experimental & Molecular …, 2021 - nature.com
Recent advances in high-throughput sequencing technologies and data science have
facilitated the development of precision medicine to treat cancer patients. Synthetic lethality …

The post-translational regulation of epithelial–mesenchymal transition-inducing transcription factors in cancer metastasis

E Kang, J Seo, H Yoon, S Cho - International journal of molecular …, 2021 - mdpi.com
Epithelial–mesenchymal transition (EMT) is generally observed in normal embryogenesis
and wound healing. However, this process can occur in cancer cells and lead to metastasis …

The epithelial-to-mesenchymal transition in development and cancer

A Francou, KV Anderson - Annual review of cancer biology, 2020 - annualreviews.org
Epithelial-to-mesenchymal transitions (EMTs) are complex cellular processes where cells
undergo dramatic changes in signaling, transcriptional programming, and cell shape, while …

Mitotic protein kinase-driven crosstalk of machineries for mitosis and metastasis

CH Kim, DE Kim, DH Kim, GH Min, JW Park… - … & Molecular Medicine, 2022 - nature.com
Accumulating evidence indicates that mitotic protein kinases are involved in metastatic
migration as well as tumorigenesis. Protein kinases and cytoskeletal proteins play a role in …

Insights into the non-mitotic functions of Aurora kinase A: more than just cell division

G Bertolin, M Tramier - Cellular and Molecular Life Sciences, 2020 - Springer
AURKA is a serine/threonine kinase overexpressed in several cancers. Originally identified
as a protein with multifaceted roles during mitosis, improvements in quantitative microscopy …

Roles of the phosphorylation of transcriptional factors in epithelial‐mesenchymal transition

R Xu, JY Won, CH Kim, DE Kim, H Yim - Journal of oncology, 2019 - Wiley Online Library
Epithelial‐to‐mesenchymal transition (EMT) is the first step in the development of the
invasive and migratory properties of cancer metastasis. Since the transcriptional …

The long noncoding RNA landscape of neuroendocrine prostate cancer and its clinical implications

VR Ramnarine, M Alshalalfa, F Mo, N Nabavi… - …, 2018 - academic.oup.com
Background Treatment-induced neuroendocrine prostate cancer (tNEPC) is an aggressive
variant of late-stage metastatic castrate-resistant prostate cancer that commonly arises …