Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …

Chromatin structure and gene expression are dynamically controlled by post-translational
modifications (PTMs) on histone proteins, including ubiquitylation, methylation, acetylation …

Chromatin structure imposes significant obstacles on all aspects of transcription that are
mediated by RNA polymerase II. The dynamics of chromatin structure are tightly regulated …

The organization of eukaryotic genomes into chromatin provides challenges for the cell to
accomplish basic cellular functions, such as transcription, DNA replication and repair of DNA …

Post-translational modifications of DNA and histones are epigenetic mechanisms, which
affect the chromatin structure, ultimately leading to gene expression changes. A number of …

Abstract Histone H3 Lys4 (H3K4) methylation is a prevalent mark associated with
transcription activation. A common feature of several H3K4 methyltransferase complexes is …

Various factors differentially recognize trimethylated histone H3 lysine 4 (H3K4me3) near
promoters, H3K4me2 just downstream, and promoter-distal H3K4me1 to modulate gene …

Recently, many of the enzymes responsible for the addition and removal of ubiquitin from
the histones H2A and H2B have been identified and characterized. From these studies, it …

The regulation of transcription by RNA polymerase II is closely intertwined with the
regulation of chromatin structure. A host of proteins required for the disassembly …

Numerous post-translational modifications of histones have been described in organisms
ranging from yeast to humans. Growing evidence for dynamic regulation of these …