The cerebellum is best known for its role in controlling motor behaviors. However, recent
work supports the view that it also influences non-motor behaviors. The contribution of the …

Abstract Objectives Treatments for Alzheimer's disease are urgently needed given its
enormous human and economic costs and disappointing results of clinical trials targeting …

Abstract Serotonin receptor 4 (5-HT4R) plays an important role in regulating mood, anxiety,
and cognition, and drugs that activate this receptor have fast-acting antidepressant (AD)-like …

Current standards for safe delivery of electrical stimulation to the central nervous system are
based on foundational studies which examined post-mortem tissue for histological signs of …

MeCP2 protein, encoded by the MECP2 gene, binds to DNA and affects transcription.
Outside of this activity the true range of MeCP2 function is still not entirely clear. As MECP2 …

Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) is a safe and
effective intervention for the treatment of certain forms of epilepsy. In preclinical models …

Depression is one of the most common mental disorders, which can lead to a variety of
emotional problems and even suicide at its worst. As this neuropsychiatric disorder causes …

Epilepsy is a neurological disorder that affects more than 70 million people globally. A
considerable proportion of epilepsy is resistant to anti-epileptic drugs (AED). For patients …

Reward induces activity-dependant gene expression and synaptic plasticity-related
changes. Lysine-specific histone demethylase 1 (LSD1), a key enzyme driving histone …

Nanotechnology has the potential to open many novel diagnostic and treatment avenues for
disorders of the central nervous system (CNS). In this review, we discuss recent …