Bioengineering human tissues and the future of vascular replacement
Cardiovascular defects, injuries, and degenerative diseases often require surgical
intervention and the use of implantable replacement material and conduits. Traditional …
intervention and the use of implantable replacement material and conduits. Traditional …
[HTML][HTML] Combined mechanistic modeling and machine-learning approaches in systems biology–A systematic literature review
Background and objective Mechanistic-based Model simulations (MM) are an effective
approach commonly employed, for research and learning purposes, to better investigate …
approach commonly employed, for research and learning purposes, to better investigate …
A predictive multiscale model of in-stent restenosis in femoral arteries: linking haemodynamics and gene expression with an agent-based model of cellular dynamics
In-stent restenosis (ISR) is a maladaptive inflammatory-driven response of femoral arteries
to percutaneous transluminal angioplasty and stent deployment, leading to lumen re …
to percutaneous transluminal angioplasty and stent deployment, leading to lumen re …
[HTML][HTML] Investigating the effect of drug release on in-stent restenosis: a hybrid continuum–agent-based modelling approach
Background and objective In-stent restenosis (ISR) following percutaneous coronary
intervention with drug-eluting stent (DES) implantation remains an unresolved issue, with …
intervention with drug-eluting stent (DES) implantation remains an unresolved issue, with …
Computational modeling of in-stent restenosis: Pharmacokinetic and pharmacodynamic evaluation
Persistence of the pathology of in-stent restenosis even with the advent of drug-eluting
stents warrants the development of highly resolved in silico models. These computational …
stents warrants the development of highly resolved in silico models. These computational …
Predicting 1-year in-stent restenosis in superficial femoral arteries through multiscale computational modelling
In-stent restenosis in superficial femoral arteries (SFAs) is a complex, multi-factorial and
multiscale vascular adaptation process whose thorough understanding is still lacking …
multiscale vascular adaptation process whose thorough understanding is still lacking …
Diversity of cells and signals in the cardiovascular system
This white paper is the outcome of the seventh UC Davis Cardiovascular Research
Symposium on Systems Approach to Understanding Cardiovascular Disease and …
Symposium on Systems Approach to Understanding Cardiovascular Disease and …
[HTML][HTML] An intricate interplay between stent drug dose and release rate dictates arterial restenosis
Since the introduction of percutaneous coronary intervention (PCI) for the treatment of
obstructive coronary artery disease (CAD), patient outcomes have progressively improved …
obstructive coronary artery disease (CAD), patient outcomes have progressively improved …
Multiscale agent-based modeling of restenosis after percutaneous transluminal angioplasty: effects of tissue damage and hemodynamics on cellular activity
Background Restenosis following percutaneous transluminal angioplasty (PTA) in femoral
arteries is a major cause of failure of the revascularization procedure. The arterial wall …
arteries is a major cause of failure of the revascularization procedure. The arterial wall …
An agent-based model of cardiac allograft vasculopathy: toward a better understanding of chronic rejection dynamics
E Serafini, A Corti, D Gallo, C Chiastra, XC Li… - … in Bioengineering and …, 2023 - frontiersin.org
Cardiac allograft vasculopathy (CAV) is a coronary artery disease affecting 50% of heart
transplant (HTx) recipients, and it is the major cause of graft loss. CAV is driven by the …
transplant (HTx) recipients, and it is the major cause of graft loss. CAV is driven by the …