Water is the solvent used by nature for biological chemistry. Considering the enormous
variety of biological organic synthetic pathways and the complicated molecular structures …

Protein design is a valuable tool for understanding the fundamental factors that dictate
protein structure and function. The field of protein design has seen significant progress over …

Organic syntheses are composed of two main types of reactions: Carbon-carbon bond
formations and functional group transformations. CC bond formation is the essence of …

Many organic chemists, myself included, will remember being told in early undergraduate
years “in organic synthesis water is a contaminant”. From the very beginning it was made …

Water has emerged as a versatile solvent for organic chemistry in recent years. Water as a
solvent is not only inexpensive and environmentally benign, but also gives completely new …

New types of Lewis acids as water-compatible catalysts have been developed. Various
metal salts were found to work as Lewis acid catalysts in aqueous media, and catalytic …

We examined the catalytic activity of substituted thioureas in a series of Diels–Alder
reactions and 1, 3‐dipolar cycloadditions. The kinetic data reveal that the observed …

We report a strategy to develop heterogeneous single‐site enantioselective catalysts based
on naturally occurring amino acids and earth‐abundant metals for eco‐friendly asymmetric …

Enantioselective Direct-Addition of Terminal Alkynes to Imines Catalyzed by Copper(I)pybox
Complex in Water and in Toluene | Journal of the American Chemical Society ACS ACS …

For 80 years, the Diels-Alder addition1–3 has been one of the best methods for the
preparation of six-membered carbocycles with control of up to four stereogenic centers in an …