Time span of literature covered: up to mid-2023 Iterative type I polyketide synthases (iPKSs)
are outstanding natural chemists: megaenzymes that repeatedly utilize their catalytic …

Covering: 1999 up to 2021 Fungal polyketides encompass a range of structurally diverse
molecules with a wide variety of biological activities. The giant multifunctional enzymes that …

Calbistrins are fungal polyketides consisting of the characteristic decalin and polyene
moieties. Although the biosynthetic gene cluster of calbistrin A was recently identified, the …

The polyketide synthase (PKS)‐like protein TerB, consisting of inactive dehydratase, inactive
C‐methyltransferase, and functional ketoreductase domains collaborates with the iterative …

Abstract Main Conclusion The novel C-methyltransferase, MaMT1, could catalyze the
conversion of piperidine to 2-methylpiperidine, which may be involved in the methylation …

A comparison of substrate‐binding site amino acid residues in the C‐methyltransferase (MT)
domains of fungal nonreducing polyketide synthases (NR‐PKSs) suggests that these …

We report synthesis of two diastereomeric structures previously proposed for the complex
secondary metabolite pseurotin A2. Both structures were accessed from the same building …

Enzyme fusion, the fusion of enzymes with different domains to a single protein, has been
widely recognized as a promising strategy in the development of biocatalysts. Nature has …

Ladderane lipids (found in the membranes of anaerobic ammonium-oxidizing [anammox]
bacteria) have unique ladder-like hydrophobic groups, and their highly strained exotic …

Microorganisms have developed diverse metabolic systems for enduring in a competitive
society of nature. While some microbial species threaten human beings as the cause of …