Whether the human fetus and the prenatal intrauterine environment (amniotic fluid and
placenta) are stably colonized by microbial communities in a healthy pregnancy remains a …

Environmental exposure plays a major role in the development of allergic diseases. The
exposome can be classified into internal (eg, aging, hormones, and metabolic processes) …

Prenatal and early postnatal life represent key periods of immune system development. In
addition to genetics and host biology, environment has a large and irreversible role in the …

Gut bacterial metabolites such as short-chain fatty acids (SCFAs) have important effects on
immune cells and the gut. SCFAs derive from the fermentation of dietary fiber by gut …

Importance Randomized clinical trials showed that earlier peanut introduction can prevent
peanut allergy in select high-risk populations. This led to changes in infant feeding …

Early life, including the establishment of the intestinal microbiome, represents a critical
window of growth and development. Postnatal factors affecting the microbiome, including …

The intestinal epithelial tract forms a dynamic lining of the digestive system consisting of a
range of epithelial cell sub-types with diverse functions fulfilling specific niches. The …

Environmental exposures during pregnancy that alter both the maternal gut microbiome and
the infant's risk of allergic disease and asthma include a traditional farm environment and …

Background Multiple studies suggest a key role for gut microbiota in IgE-mediated food
allergy (FA) development, but to date, none has studied it in the persistent state. Methods To …

The maternal microbiome is essential for the healthy growth and development of offspring
and has long-term effects later in life. Recent advances indicate that the maternal …