Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …

ABSTRACT Selenoprotein GPX4 (glutathione peroxidase 4), originally known as PHGPX
(phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use …

Understanding the intricate molecular machinery that governs ferroptosis and leveraging
this accumulating knowledge could facilitate disease prevention, diagnosis, treatment, and …

Ferroptosis, first proposed in 2012, is an iron-dependent form of regulated cell death
characterized by excessive polyunsaturated fatty acid oxidation. In the past decade …

Ferroptosis is a non‐apoptotic programmed cell death caused by the accumulation of lipid
peroxide. System Xc‐/glutathione peroxidase 4 (GPX4) axis and iron axis are two main …

Immunotherapy has received widespread attention for its effective and long‐term tumor‐
eliminating ability. However, for immunogenic “cold” tumors, such as prostate cancer (PCa) …

Triple-negative breast cancer (TNBC) is a highly lethal malignancy, and its clinical
management encounters severe challenges due to its high metastatic propensity and the …

Regulated cell death (RCD) controls the removal of dispensable, infected or malignant cells,
and is thus essential for development, homeostasis and immunity of multicellular organisms …

Targeted therapies in cancer treatment can improve in vivo efficacy and reduce adverse
effects by altering the tissue exposure of specific biomolecules. However, there are still large …

Abstract Glutathione peroxidase 4 (GPX4) is the most promising target for inducing
ferroptosis. GPX4-targeting strategies primarily focus on inhibiting its activity or adjusting its …