[HTML][HTML] Integrins in cancer: Emerging mechanisms and therapeutic opportunities
F Liu, Q Wu, Z Dong, K Liu - Pharmacology & therapeutics, 2023 - Elsevier
Integrins are vital surface adhesion receptors that mediate interactions between the
extracellular matrix (ECM) and cells and are essential for cell migration and the …
extracellular matrix (ECM) and cells and are essential for cell migration and the …
Targeting PI3K family with small-molecule inhibitors in cancer therapy: current clinical status and future directions
H Li, X Wen, Y Ren, Z Fan, J Zhang, G He, L Fu - Molecular Cancer, 2024 - Springer
Abstract The Phosphatidylinositol-3-kinase (PI3K) family is well-known to comprise three
classes of intracellular enzymes. Class I PI3Ks primarily function in signaling by responding …
classes of intracellular enzymes. Class I PI3Ks primarily function in signaling by responding …
Targeting class I-II-III PI3Ks in cancer therapy: recent advances in tumor biology and preclinical research
B Thibault, F Ramos-Delgado, J Guillermet-Guibert - Cancers, 2023 - mdpi.com
Simple Summary The PI3K/AKT pathway is one of the most important signaling nodes in
cancer. While class I PI3K roles in cancer are well known, class II and III functions in …
cancer. While class I PI3K roles in cancer are well known, class II and III functions in …
Identification of a targeted ACSL4 inhibitor to treat ferroptosis-related diseases
Q Huang, Y Ru, Y Luo, X Luo, D Liu, Y Ma, X Zhou… - Science …, 2024 - science.org
Ferroptosis is a form of iron-dependent, lipid peroxidation–driven regulatory cell death that
has been implicated in the pathogenesis of multiple diseases, including organ injury …
has been implicated in the pathogenesis of multiple diseases, including organ injury …
Endothelial Injury and Repair of the Chronic Allograft Vasculopathy of Heart Allografts
AG Masoud - 2022 - era.library.ualberta.ca
Heart transplantation (HTx) is a life-saving intervention for patients with end-stage heart
failure. Nonetheless, the development of Chronic Allograft Vasculopathy (CAV) limits the …
failure. Nonetheless, the development of Chronic Allograft Vasculopathy (CAV) limits the …
Mechanical compressive forces increase PI3K output signaling in breast and pancreatic cancer cells
M Di-Luoffo, C Schmitter, EC Barrere, N Therville… - bioRxiv, 2021 - biorxiv.org
Mechanical stresses, including compressive stress, are well-recognized as being inherently
triggered during cancer development. They are integrated by cells in biochemical signals …
triggered during cancer development. They are integrated by cells in biochemical signals …
Isoform-selective targeting of PI3K: time to consider new opportunities?
Abstract Phosphoinositide-3-kinases (PI3Ks) are central to several cellular signaling
pathways in human physiology and are potential pharmacological targets for many …
pathways in human physiology and are potential pharmacological targets for many …