Cancer stem-like cells (CSCs) contribute to the tumorigenicity, progression, and
chemoresistance of cancers. It is not known whether CSCs arise from normal stem cells or if …

Pancreatic adenocarcinoma is a malignancy with rising incidence and grim prognosis.
Despite improvements in therapeutics for treating metastatic pancreatic cancer, this disease …

The germline cells are essential for the propagation of human beings, thus essential for the
survival of mankind. The germline stem cells, as a unique cell type, generate various states …

Testicular germ cell tumours (TGCTs) rank as the most common malignancy in men aged 20‐
34 years, and seminomas are the most type of TGCTs. As a crucial anti‐tumour agent with …

Background Our previous work shows Autophagy enhanced resistance to cisplatin in
seminoma. The expression of the N6-methyladenosine (m6A) methyltransferases METTL3 …

Lung cancer is the leading cause of cancer‐associated death, and non‐small cell lung
cancer (NSCLC) accounts for 85% of all lung cancer cases. Many drugs have been used to …

Current treatment regimens for type II testicular germ cell tumours (TGCTs) achieve cure
rates of≥ 95%; however, 1–5% of TGCTs develop resistance to standard platinum-based …

Cisplatin resistance in testicular germ cell tumors (TGCTs) is a clinical challenge. We
investigated the underlying mechanisms associated with cancer stem cell (CSC) markers …

Simple Summary Near-infrared photoimmunotherapy (NIR-PIT) is a novel molecularly-
targeted therapy that induces rapid cancer cell death by systemically administering an …

Purpose Cisplatin can cause a variety of DNA crosslink lesions including intra-strand and
inter-strand crosslinks (ICLs), which are associated with the sensitivity of cancer cells to …