Engineering strategies for enhanced production of protein and bio-products in Pichia pastoris: a review

Z Yang, Z Zhang - Biotechnology advances, 2018 - Elsevier
Pichia pastoris has been recognized as one of the most industrially important hosts for
heterologous protein production. Despite its high protein productivity, the optimization of P …

Making recombinant proteins in filamentous fungi-are we expecting too much?

H Nevalainen, R Peterson - Frontiers in microbiology, 2014 - frontiersin.org
Hosts used for the production of recombinant proteins are typically high-protein secreting
mutant strains that have been selected for a specific purpose, such as efficient production of …

A Systematic Review of the Potential of Pichia pastoris (Komagataella phaffii) as an Alternative Host for Biologics Production

VE Vijayakumar, K Venkataraman - Molecular Biotechnology, 2024 - Springer
The methylotrophic yeast Pichia pastoris is garnering interest as a chassis cell factory for the
manufacture of recombinant proteins because it effectively satisfies the requirements of both …

The advent of plant cells in bioreactors

F Verdú-Navarro, JA Moreno-Cid, J Weiss… - Frontiers in Plant …, 2023 - frontiersin.org
Ever since agriculture started, plants have been bred to obtain better yields, better fruits, or
sustainable products under uncertain biotic and abiotic conditions. However, a new way to …

Cellular and molecular effects of yeast probiotics on cancer

A Saber, B Alipour, Z Faghfoori… - Critical reviews in …, 2017 - Taylor & Francis
The cancer is one of the main causes of human deaths worldwide. The exact mechanisms of
initiation and progression of malignancies are not clear yet, but there is a common …

The microalga Dunaliella and its applications: a review

M Barbosa, LG Inácio, C Afonso, P Maranhão - Applied Phycology, 2023 - Taylor & Francis
Green microalgae in the genus Dunaliella have become increasingly important in
biotechnology and industry. The high adaptability of Dunaliella to high salinity, as well as its …

Interferon-based biopharmaceuticals: Overview on the production, purification, and formulation

LS Castro, GS Lobo, P Pereira, MG Freire, MC Neves… - Vaccines, 2021 - mdpi.com
The advent of biopharmaceuticals in modern medicine brought enormous benefits to the
treatment of numerous human diseases and improved the well-being of many people …

The α-mating factor secretion signals and endogenous signal peptides for recombinant protein secretion in Komagataella phaffii

C Zou, L Lu, S Wang, C Zhang, X Chen, Y Lin… - … for Biofuels and …, 2022 - Springer
Abstract Background The budding yeast Komagataella phaffii (Pichia pastoris) is widely
employed to secrete proteins of academic and industrial interest. For secretory proteins …

Organic wastes as feedstocks for non-conventional yeast-based bioprocesses

DTH Do, CW Theron, P Fickers - Microorganisms, 2019 - mdpi.com
Non-conventional yeasts are efficient cell factories for the synthesis of value-added
compounds such as recombinant proteins, intracellular metabolites, and/or metabolic by …

Comparative genome‐scale analysis of Pichia pastoris variants informs selection of an optimal base strain

JR Brady, CA Whittaker, MC Tan… - Biotechnology and …, 2020 - Wiley Online Library
Komagataella phaffii, also known as Pichia pastoris, is a common host for the production of
biologics and enzymes, due to fast growth, high productivity, and advancements in host …