Biocatalysis is a highly valued enabling technology for pharmaceutical research and
development as it can unlock synthetic routes to complex chiral motifs with unparalleled …

The review compiles artificial cascades involving enzymes with a focus on the last 10 years.
A cascade is defined as the combination of at least two reaction steps in a single reaction …

Covering: up to the beginning of 2020 Enzymes depending on cofactors are essential in
many biosynthetic pathways of natural products. They are often involved in key steps …

In this review the current state‐of‐the‐art of S‐adenosylmethionine (SAM)‐dependent
methyltransferases and SAM are evaluated. Their structural classification and diversity is …

Adenosine triphosphate (ATP) is a central metabolite that plays an indispensable role in
various cellular processes, from energy supply to cell‐to‐cell signaling. Nature has …

Enzyme catalysis, enabled by advances in protein engineering and directed evolution, is
beginning to transform chemical synthesis in the pharmaceutical industry. This review …

Metabolic engineering efforts that harness living organisms to produce natural products and
other useful chemicals face inherent difficulties because the maintenance of life processes …

S‐Adenosylmethionine‐dependent methyltransferases are versatile tools for the specific
alkylation of many compounds, such as pharmaceuticals, but their biocatalytic application is …

Highlights•In vitro, multi-enzyme cascades of industrial relevance are reviewed.•Enzyme
evolution allows combining multiple enzymatic steps in a single reaction step within a single …

Enzymes are nature's catalyst of choice for the highly selective and efficient coupling of
carbohydrates. Enzymatic sugar coupling is a competitive technology for industrial …