CuAAC-ensembled 1, 2, 3-triazole-linked isosteres as pharmacophores in drug discovery
A Rani, G Singh, A Singh, U Maqbool, G Kaur… - RSC advances, 2020 - pubs.rsc.org
The review lays emphasis on the significance of 1, 2, 3-triazoles synthesized via CuAAC
reaction having potential to act as anti-microbial, anti-cancer, anti-viral, anti-inflammatory …
reaction having potential to act as anti-microbial, anti-cancer, anti-viral, anti-inflammatory …
Design, synthesis, and antimicrobial activities of 1, 2, 3-triazole glycoside clickamers
Bacterial resistance remains a significant threat and a leading cause of death worldwide,
despite massive attempts to control infections. In an effort to develop biologically active …
despite massive attempts to control infections. In an effort to develop biologically active …
Magnetic nanoparticle embedded chitosan-based polymeric network for the hydrophobic drug delivery of paclitaxel
V Manjusha, MR Rajeev, TS Anirudhan - International Journal of Biological …, 2023 - Elsevier
Safe delivery of hydrophobic drugs to the tumor site is a major problem for the scientific
community. To improve the in vivo efficacy of hydrophobic drugs by avoiding solubility …
community. To improve the in vivo efficacy of hydrophobic drugs by avoiding solubility …
Pluronic F-127 hydrogels containing copper oxide nanoparticles and a nitric oxide donor to treat skin cancer
Melanoma is a serious and aggressive type of skin cancer with growing incidence, and it is
the leading cause of death among those affected by this disease. Although surgical …
the leading cause of death among those affected by this disease. Although surgical …
Synthesis and Anticancer Activity of Novel Derivatives of α,β‐Unsaturated Ketones Based on Oleanolic Acid: in Vitro and in Silico Studies against Prostate Cancer …
H Şenol, M Ghaffari‐Moghaddam, Ş Bulut… - Chemistry & …, 2023 - Wiley Online Library
Herein, new derivatives of α, β‐unsaturated ketones based on oleanolic acid (4 a–i) were
designed, synthesized, characterized, and tested against human prostate cancer (PC3) …
designed, synthesized, characterized, and tested against human prostate cancer (PC3) …
Synthesis, antimalarial and antioxidant activity of coumarin appended 1, 4-disubstituted 1, 2, 3-triazoles
CP Kaushik, M Chahal - Monatshefte für Chemie-Chemical Monthly, 2021 - Springer
A series of coumarin appended triazole hybrids of biotic interest was synthesized through
click chemistry approach from the coumarin based terminal alkynes and aromatic azides. All …
click chemistry approach from the coumarin based terminal alkynes and aromatic azides. All …
σ-Acetylide complexes for biomedical applications: Features, challenges and future directions
Mono-, di-and polynuclear metal alkynyl or σ-acetylide complexes have attracted a great
deal of interest due to their multi-dimensional applications. In the past few decades, several …
deal of interest due to their multi-dimensional applications. In the past few decades, several …
In vitro anticancer activity of Pd (II) complexes with pyridine scaffold: Their bioactivity, role in cell cycle arrest, and computational study
A series of Pd (II) based complexes [Pd (PEA) Cl 2]; Pd1,[Pd (PEA)(H 2 O) 2] 2+; Pd2,[Pd
(PEA)(DL-meth)] 2+; Pd3,[Pd (PEA)(DL-pen)]+; Pd4,[Pd (PEA)(OX)]; Pd5 and [Pd …
(PEA)(DL-meth)] 2+; Pd3,[Pd (PEA)(DL-pen)]+; Pd4,[Pd (PEA)(OX)]; Pd5 and [Pd …
Acridine Based N-Acylhydrazone Derivatives as Potential Anticancer Agents: Synthesis, Characterization and ctDNA/HSA Spectroscopic Binding Properties
M Vilková, M Hudáčová, N Palušeková… - Molecules, 2022 - mdpi.com
A series of novel acridine N-acylhydrazone derivatives have been synthesized as potential
topoisomerase I/II inhibitors, and their binding (calf thymus DNA—ctDNA and human serum …
topoisomerase I/II inhibitors, and their binding (calf thymus DNA—ctDNA and human serum …
Development of cyclodextrin-functionalized transethoniosomes of 6-gingerol: statistical optimization, in vitro characterization and assessment of cytotoxic and anti …
The poor solubility and stability of 6-gingerol (6-G) could hamper its clinical applications.
The aim of the current study was to develop a novel ultra-deformable cyclodextrin …
The aim of the current study was to develop a novel ultra-deformable cyclodextrin …