CuAAC-ensembled 1, 2, 3-triazole-linked isosteres as pharmacophores in drug discovery

A Rani, G Singh, A Singh, U Maqbool, G Kaur… - RSC advances, 2020 - pubs.rsc.org
The review lays emphasis on the significance of 1, 2, 3-triazoles synthesized via CuAAC
reaction having potential to act as anti-microbial, anti-cancer, anti-viral, anti-inflammatory …

Design, synthesis, and antimicrobial activities of 1, 2, 3-triazole glycoside clickamers

T El Malah, HF Nour, AAE Satti, BA Hemdan… - Molecules, 2020 - mdpi.com
Bacterial resistance remains a significant threat and a leading cause of death worldwide,
despite massive attempts to control infections. In an effort to develop biologically active …

Magnetic nanoparticle embedded chitosan-based polymeric network for the hydrophobic drug delivery of paclitaxel

V Manjusha, MR Rajeev, TS Anirudhan - International Journal of Biological …, 2023 - Elsevier
Safe delivery of hydrophobic drugs to the tumor site is a major problem for the scientific
community. To improve the in vivo efficacy of hydrophobic drugs by avoiding solubility …

Pluronic F-127 hydrogels containing copper oxide nanoparticles and a nitric oxide donor to treat skin cancer

FV Cabral, BM Santana, CN Lange, BL Batista… - Pharmaceutics, 2023 - mdpi.com
Melanoma is a serious and aggressive type of skin cancer with growing incidence, and it is
the leading cause of death among those affected by this disease. Although surgical …

Synthesis and Anticancer Activity of Novel Derivatives of α,β‐Unsaturated Ketones Based on Oleanolic Acid: in Vitro and in Silico Studies against Prostate Cancer …

H Şenol, M Ghaffari‐Moghaddam, Ş Bulut… - Chemistry & …, 2023 - Wiley Online Library
Herein, new derivatives of α, β‐unsaturated ketones based on oleanolic acid (4 a–i) were
designed, synthesized, characterized, and tested against human prostate cancer (PC3) …

Synthesis, antimalarial and antioxidant activity of coumarin appended 1, 4-disubstituted 1, 2, 3-triazoles

CP Kaushik, M Chahal - Monatshefte für Chemie-Chemical Monthly, 2021 - Springer
A series of coumarin appended triazole hybrids of biotic interest was synthesized through
click chemistry approach from the coumarin based terminal alkynes and aromatic azides. All …

σ-Acetylide complexes for biomedical applications: Features, challenges and future directions

A Haque, RA Al-Balushi, MS Khan - Journal of Organometallic Chemistry, 2019 - Elsevier
Mono-, di-and polynuclear metal alkynyl or σ-acetylide complexes have attracted a great
deal of interest due to their multi-dimensional applications. In the past few decades, several …

In vitro anticancer activity of Pd (II) complexes with pyridine scaffold: Their bioactivity, role in cell cycle arrest, and computational study

R Bhaduri, A Pan, SK Tarai, S Mandal, A Bagchi… - Journal of Molecular …, 2022 - Elsevier
A series of Pd (II) based complexes [Pd (PEA) Cl 2]; Pd1,[Pd (PEA)(H 2 O) 2] 2+; Pd2,[Pd
(PEA)(DL-meth)] 2+; Pd3,[Pd (PEA)(DL-pen)]+; Pd4,[Pd (PEA)(OX)]; Pd5 and [Pd …

Acridine Based N-Acylhydrazone Derivatives as Potential Anticancer Agents: Synthesis, Characterization and ctDNA/HSA Spectroscopic Binding Properties

M Vilková, M Hudáčová, N Palušeková… - Molecules, 2022 - mdpi.com
A series of novel acridine N-acylhydrazone derivatives have been synthesized as potential
topoisomerase I/II inhibitors, and their binding (calf thymus DNA—ctDNA and human serum …

Development of cyclodextrin-functionalized transethoniosomes of 6-gingerol: statistical optimization, in vitro characterization and assessment of cytotoxic and anti …

EA Mazyed, FA Badria, MH ElNaggar, SM El-Masry… - Pharmaceutics, 2022 - mdpi.com
The poor solubility and stability of 6-gingerol (6-G) could hamper its clinical applications.
The aim of the current study was to develop a novel ultra-deformable cyclodextrin …