On the molecular nature of large-pore channels
J Syrjanen, K Michalski, T Kawate… - Journal of molecular …, 2021 - Elsevier
Membrane transport is a fundamental means to control basic cellular processes such as
apoptosis, inflammation, and neurodegeneration and is mediated by a number of …
apoptosis, inflammation, and neurodegeneration and is mediated by a number of …
A 30-year journey from volume-regulated anion currents to molecular structure of the LRRC8 channel
The swelling-activated anion channel VRAC has fascinated and frustrated physiologists
since it was first described in 1988. Multiple laboratories have defined VRAC's biophysical …
since it was first described in 1988. Multiple laboratories have defined VRAC's biophysical …
The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling
AR Concepcion, LE Wagner, J Zhu, AY Tao… - Nature …, 2022 - nature.com
The volume-regulated anion channel (VRAC) is formed by LRRC8 proteins and is
responsible for the regulatory volume decrease (RVD) after hypotonic cell swelling. Besides …
responsible for the regulatory volume decrease (RVD) after hypotonic cell swelling. Besides …
[HTML][HTML] LRRC8A: C/E heteromeric channels are ubiquitous transporters of cGAMP
Summary Extracellular 2′ 3′-cyclic-GMP-AMP (cGAMP) is an immunotransmitter exported
by diseased cells and imported into host cells to activate the innate immune STING pathway …
by diseased cells and imported into host cells to activate the innate immune STING pathway …
Structures of human pannexin 1 reveal ion pathways and mechanism of gating
Abstract Pannexin 1 (PANX1) is an ATP-permeable channel with critical roles in a variety of
physiological functions such as blood pressure regulation, apoptotic cell clearance and …
physiological functions such as blood pressure regulation, apoptotic cell clearance and …
[HTML][HTML] Glutamate-releasing SWELL1 channel in astrocytes modulates synaptic transmission and promotes brain damage in stroke
By releasing glutamate, astrocytes actively regulate synaptic transmission and contribute to
excitotoxicity in neurological diseases. However, the mechanisms of astrocytic glutamate …
excitotoxicity in neurological diseases. However, the mechanisms of astrocytic glutamate …
[HTML][HTML] Structure of human CALHM1 reveals key locations for channel regulation and blockade by ruthenium red
JL Syrjänen, M Epstein, R Gómez… - Nature …, 2023 - nature.com
Abstract Calcium homeostasis modulator 1 (CALHM1) is a voltage-dependent channel
involved in neuromodulation and gustatory signaling. Despite recent progress in the …
involved in neuromodulation and gustatory signaling. Despite recent progress in the …
Structural basis for assembly and lipid-mediated gating of LRRC8A: C volume-regulated anion channels
DM Kern, J Bleier, S Mukherjee, JM Hill… - Nature Structural & …, 2023 - nature.com
Leucine-rich repeat-containing protein 8 (LRRC8) family members form volume-regulated
anion channels activated by hypoosmotic cell swelling. LRRC8 channels are ubiquitously …
anion channels activated by hypoosmotic cell swelling. LRRC8 channels are ubiquitously …
LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses
LRRC8 family proteins on the plasma membrane play a critical role in cellular
osmoregulation by forming volume-regulated anion channels (VRACs) necessary to prevent …
osmoregulation by forming volume-regulated anion channels (VRACs) necessary to prevent …
[HTML][HTML] Cryo-EM structure of human heptameric pannexin 2 channel
H Zhang, S Wang, Z Zhang, M Hou, C Du… - Nature …, 2023 - nature.com
Abstract Pannexin 2 (Panx2) is a large-pore ATP-permeable channel with critical roles in
various physiological processes, such as the inflammatory response, energy production and …
various physiological processes, such as the inflammatory response, energy production and …