BACKGROUND The discovery of kisspeptin as key central regulator of GnRH secretion has
led to a new level of understanding of the neuroendocrine regulation of human reproduction …

Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

Kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged
as key players in the regulation of reproduction. Mutations in humans or genetically targeted …

Identification, in late 2003, of inactivating mutations of the G protein-coupled receptor
GPR54 as causative factor for absence of puberty and hypogonadotropic hypogonadism in …

Gonadotropin hormone-releasing hormone (GnRH) is the key regulator of the reproductive
axis. Its pulsatile secretion determines the pattern of secretion of the gonadotropins follicle …

GnRH neurons play a pivotal role in the central regulation of fertility. Kisspeptin greatly
increases GnRH/LH release and GnRH neuron firing activity and may be involved in …

Kisspeptin (KP) and neurokinin B (NKB) are neuropeptides that govern the reproductive
endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) …

Context: Kisspeptin, the endogenous ligand of the G protein-coupled receptor 54, is a key
regulator of the hypothalamo-pituitary-gonadal (HPG) axis. GPR54-null mice exhibit …

Normal reproductive functioning in mammals depends upon gonadotropin-releasing
hormone (GnRH) neurons generating a pulsatile pattern of gonadotropin secretion. The …

We determined whether kisspeptin could be used to manipulate the gonadotropin axis and
ovulation in sheep. First, a series of experiments was performed to determine the …