Although the cytotoxic effects of viruses are usually viewed in terms of pathogenicity, it is
possible to harness this activity for therapeutic purposes. Viral genomes are highly versatile …

Direct targeting of cancer cells with gene therapy has the potential to treat cancer on the
basis of its molecular characteristics. But although laboratory results have been extremely …

Green tea catechins have been reported to inhibit proteases involved in cancer metastasis
and infection by influenza virus and HIV. To date there are no effective anti-adenoviral …

In the evolutionary battle between viruses and their hosts, viruses have armed themselves
with weapons to defeat the host's attacks on infected cells. Various proteins encoded in the …

Recombinant adenovirus (rAd) and recombinant adeno-associated virus (rAAV) are among
the most extensively used vectors in gene therapy studies to date. These two vectors share …

In the search for novel strategies, oncolytic virotherapy has recently emerged as a viable
approach to specifically kill tumor cells. Unlike conventional gene therapy, it uses replication …

Cancer-specificity is the key requirement for a drug or treatment regimen to be effective
against malignant disease—and has rarely been achieved adequately to date. Therefore …

The resistance of cancers to conventional therapies has inspired the search for novel
strategies. One such approach, namely gene therapy, is based upon the introduction of …

We have engineered a human adenovirus, ONYX-411, that selectively replicates in human
tumor cells, but not normal cells, depending upon the status of their retinoblastoma tumor …

Adenoviruses (Ads) have gained popularity as gene delivery vectors for therapeutic and
prophylactic applications. Ad entry into host cells involves specific interactions between cell …