Mitochondria as potential targets in Alzheimer disease therapy: an update

G Cenini, W Voos - Frontiers in pharmacology, 2019 - frontiersin.org
Alzheimer disease (AD) is a progressive and deleterious neurodegenerative disorder that
affects mostly the elderly population. At the moment, no effective treatments are available in …

Cyclodextrins, natural compounds, and plant bioactives—a nutritional perspective

S Wüpper, K Lüersen, G Rimbach - Biomolecules, 2021 - mdpi.com
Cyclodextrins (CDs) are a group of cyclic oligosaccharides produced from starch or starch
derivatives. They contain six (αCD), seven (βCD), eight (γCD), or more glucopyranose …

Therapeutic potential of palm oil vitamin E-derived tocotrienols in inflammation and chronic diseases: Evidence from preclinical and clinical studies

Z Zainal, H Khaza'ai, AK Radhakrishnan… - Food Research …, 2022 - Elsevier
Palm oil is rich in tocotrienols (T3s), a type of vitamin E that has garnered considerable
research interest as it exhibits anti-inflammatory as well as antioxidant characteristics that …

Mitochondrial dysfunctions: a red thread across neurodegenerative diseases

S Stanga, A Caretto, M Boido, A Vercelli - International journal of …, 2020 - mdpi.com
Mitochondria play a central role in a plethora of processes related to the maintenance of
cellular homeostasis and genomic integrity. They contribute to preserving the optimal …

Potential role of tocotrienols on non-communicable diseases: a review of current evidence

SK Wong, Y Kamisah, N Mohamed, N Muhammad… - Nutrients, 2020 - mdpi.com
Tocotrienol (T3) is a subfamily of vitamin E known for its wide array of medicinal properties.
This review aimed to summarize the health benefits of T3, particularly in prevention or …

[HTML][HTML] Targeting mitochondrial bioenergetics as a promising therapeutic strategy in metabolic and neurodegenerative diseases

GK Bhatti, A Gupta, P Pahwa, N Khullar, S Singh… - biomedical …, 2022 - Elsevier
Mitochondria are the organelles that generate energy for the cells and act as biosynthetic
and bioenergetic factories, vital for normal cell functioning and human health. Mitochondrial …

Physiological and pathological functions of neuronal hemoglobin: a key underappreciated protein in Parkinson's disease

R Zheng, Y Yan, J Pu, B Zhang - International Journal of Molecular …, 2022 - mdpi.com
The expression of Hemoglobin (Hb) is not restricted to erythrocytes but is also present in
neurons. Hb is selectively enriched in vulnerable mesencephalic dopaminergic neurons of …

Testosterone upregulates the expression of mitochondrial ND1 and ND4 and alleviates the oxidative damage to the nigrostriatal dopaminergic system in …

W Yan, Y Kang, X Ji, S Li, Y Li, G Zhang… - Oxidative medicine …, 2017 - Wiley Online Library
Testosterone deficiency, as a potential risk factor for aging and aging‐related
neurodegenerative disorders, might induce mitochondrial dysfunction and facilitate the …

A review on the relationship between tocotrienol and Alzheimer disease

KY Chin, SS Tay - Nutrients, 2018 - mdpi.com
Alzheimer's disease (AD) is plaguing the aging population worldwide due to its tremendous
health care and socioeconomic burden. Current treatment of AD only offers symptomatic …

[HTML][HTML] Mitochondria research and neurodegenerative diseases: On the track to understanding the biological world of high complexity

D Mendes, F Peixoto, MM Oliveira, PB Andrade… - Mitochondrion, 2022 - Elsevier
From the simple unicellular eukaryote to the highly complex multicellular organism like
Human, mitochondrion emerges as a ubiquitous player to ensure the organism's …