Determining the causes of schizophrenia has been a notoriously intractable problem,
resistant to a multitude of investigative approaches over centuries. In recent decades …

A growing community is constructing a next-generation file format (NGFF) for bioimaging to
overcome problems of scalability and heterogeneity. Organized by the Open Microscopy …

Hippocampome. org is a mature open-access knowledge base of the rodent hippocampal
formation focusing on neuron types and their properties. Previously, Hippocampome. org v1 …

Drug discovery is a generally inefficient and capital-intensive process. For
neurodegenerative diseases (NDDs), the development of novel therapeutics is particularly …

Digital reconstructions provide an accurate and reliable way to store, share, model, quantify,
and analyze neural morphology. Continuous advances in cellular labeling, tissue …

Abstract 3D standard reference brains serve as key resources to understand the spatial
organization of the brain and promote interoperability across different studies. However …

Brain atlases are widely used in neuroscience as resources for conducting experimental
studies, and for integrating, analyzing, and reporting data from animal models. A variety of …

We conducted a large-scale study of whole-brain morphometry, analyzing 3.7 peta-voxels of
mouse brain images at the single-cell resolution, producing one of the largest multi …

During development, brain regions follow encoded growth trajectories. Compared to
classical brain growth charts, high-definition growth charts could quantify regional volumetric …

Comprehensive quantification of neuronal architectures underlying anatomical brain
connectivity remains challenging. We introduce a method to identify distinct axonal …