[HTML][HTML] Cortical and striatal circuits in Huntington's disease
S Blumenstock, I Dudanova - Frontiers in neuroscience, 2020 - frontiersin.org
Huntington's disease (HD) is a hereditary neurodegenerative disorder that typically
manifests in midlife with motor, cognitive, and/or psychiatric symptoms. The disease is …
manifests in midlife with motor, cognitive, and/or psychiatric symptoms. The disease is …
Early Changes in Striatal Activity and Motor Kinematics in a Huntington's Disease Mouse Model
Background Huntington's disease is a progressive neurodegenerative disorder with no
disease‐modifying treatments. Patients experience motor, cognitive, and psychiatric …
disease‐modifying treatments. Patients experience motor, cognitive, and psychiatric …
Local field potential (LFP) power and phase-amplitude coupling (PAC) changes in the striatum and motor cortex reflect neural mechanisms associated with …
C Reakkamnuan, E Kumarnsit, D Cheaha - Progress in Neuro …, 2023 - Elsevier
Impairments in motor control are the primary feature of Parkinson's disease, which is caused
by dopaminergic imbalance in the basal ganglia. Identification of neural biomarkers of …
by dopaminergic imbalance in the basal ganglia. Identification of neural biomarkers of …
[HTML][HTML] A biophysical model of striatal microcircuits suggests gamma and beta oscillations interleaved at delta/theta frequencies mediate periodicity in motor control
JAK Chartove, MM McCarthy… - PLoS computational …, 2020 - journals.plos.org
Striatal oscillatory activity is associated with movement, reward, and decision-making, and
observed in several interacting frequency bands. Local field potential recordings in rodent …
observed in several interacting frequency bands. Local field potential recordings in rodent …
Longitudinal multimodal MRI characterization of a knock-in mouse model of Huntington's disease reveals early gray and white matter alterations
Pathogenesis of the inherited neurodegenerative disorder Huntington's disease (HD) is
progressive with a long presymptomatic phase in which subtle changes occur up to 15 years …
progressive with a long presymptomatic phase in which subtle changes occur up to 15 years …
[HTML][HTML] Altered cortical processing of sensory input in Huntington disease mouse models
Huntington disease (HD), a hereditary neurodegenerative disorder, manifests as
progressively impaired movement and cognition. Although early abnormalities of neuronal …
progressively impaired movement and cognition. Although early abnormalities of neuronal …
[HTML][HTML] Heterogeneous mechanisms for synchronization of networks of resonant neurons under different E/I balance regimes
Rhythmic synchronization of neuronal firing patterns is a widely present phenomenon in the
brain—one that seems to be essential for many cognitive processes. A variety of …
brain—one that seems to be essential for many cognitive processes. A variety of …
[HTML][HTML] Striatal network modeling in Huntington's Disease
A Ponzi, SJ Barton, KD Bunner… - PLoS computational …, 2020 - journals.plos.org
Medium spiny neurons (MSNs) comprise over 90% of cells in the striatum. In vivo MSNs
display coherent burst firing cell assembly activity patterns, even though isolated MSNs do …
display coherent burst firing cell assembly activity patterns, even though isolated MSNs do …
[HTML][HTML] Early impairment of thalamocortical circuit activity and coherence in a mouse model of Huntington's disease
Huntington's disease (HD) is a progressive, fatal neurodegenerative disorder characterized
by motor, cognitive, and psychiatric disturbances. There is no known cure for HD, but its …
by motor, cognitive, and psychiatric disturbances. There is no known cure for HD, but its …
Locomotor activity and resting local field potential oscillatory rhythms of 6-OHDA mouse model of Parkinson's disease in response to acute and repeated treatments …
Phase-amplitude coupling (PAC) of local field potential (LFP) has been recognized as
higher-order representation of brain states. Neuronal loss in the striatum leads to …
higher-order representation of brain states. Neuronal loss in the striatum leads to …