Aging is the key risk factor for cognitive decline, yet the molecular changes underlying brain
aging remain poorly understood. Here, we conducted spatiotemporal RNA sequencing of …

Progress made by the medical community in increasing lifespans comes with the costs of
increasing the incidence and prevalence of age-related diseases, neurodegenerative ones …

Aging is characterized by a gradual decline of the body's biological functions, which can
lead to increased production of reactive oxygen species (ROS). Antioxidants neutralize ROS …

Neurodegenerative diseases are a leading cause of death worldwide with no cures
identified. Thus, there is a critical need for preventative measures and treatments as the …

Background: Aging is a global health challenge that is associated with a decline in cognitive
function. In the United States, most older adults (≥ 50 years) do not meet the recommended …

Objective Impaired glymphatic waste clearance function during brain aging leads to the
accumulation of metabolic waste and neurotoxic proteins (eg, amyloid-β, tau) which …

The mitochondrial theory of aging is characterized by mitochondrial electron transport chain
dysfunction. As a hallmark of aging, an increasing number of investigations have attempted …

Background: Alzheimer's disease (AD) is a neurodegenerative impairment mainly
recognized by memory loss and cognitive deficits. However, the current therapies against …

The mammalian nervous system is impacted by aging. Aging alters brain architecture, is
associated with molecular damage, and can manifest with cognitive and motor deficits that …

Current shreds of evidence point to the entorhinal cortex (EC) as the origin of the
Alzheimer's disease (AD) pathology in the cerebrum. Compared with other cortical areas …