Excitatory amino acid transporters (EAATs) encompass a class of five transporters with
distinct expression in neurons and glia of the central nervous system (CNS). EAATs are …

Disturbances of lipid homeostasis in cells provoke human diseases. The elucidation of the
underlying mechanisms and the development of efficient therapies represent formidable …

Cyclodextrin (CD), a cyclic oligosaccharide, is a pharmaceutical additive that improves the
solubility of hydrophobic compounds. Recent research has focused on the potential active …

Hedgehog, a developmental morphogen, and its downstream signalling have recently been
associated with metabolic control. Sonic hedgehog signalling (Shh) is a significant pathway …

There is growing evidence that the complex clinical manifestations of lysosomal storage
diseases (LSDs) are not fully explained by the engorgement of the endosomal-autophagic …

Abstract The Niemann-Pick type C1 (NPC1) disease is a neurodegenerative lysosomal
storage disorder due to mutations in the NPC1 gene, encoding a transmembrane protein …

Cyclic-GMP is a second messenger in phototransduction, a G-protein signaling cascade that
conveys photon absorption by rhodopsin to a change in current at the rod photoreceptor …

Autism spectrum disorders (ASDs) present a wide range of symptoms characterized by
altered sociability, compromised communication and stereotypic/repetitive behaviors. These …

A hallmark of Niemann-Pick disease, type C (NPC) is the progressive degeneration of
Purkinje neurons in the cerebellum caused by the accumulation of free cholesterol and …

Myelinating oligodendrocytes (OLs) establish saltatory nerve conduction during white matter
development. Thus, interference with oligodendrogenesis leads to an adverse outcome on …