The use of force probes to induce unfolding and refolding of single molecules through the
application of mechanical tension, known as single-molecule force spectroscopy (SMFS) …

Topologically knotted proteins have entangled structural elements within their native
structures that cannot be disentangled simply by pulling from the N-and C-termini …

The field of mechanically interlocked molecules (MIMs) has advanced rapidly in recent
years, with much work focused on their use in materials, sensing, and catalysis. However …

De novo protein design methods can create proteins with folds not yet seen in nature. These
methods largely focus on optimizing the compatibility between the designed sequence and …

The fact that proteins can have their chain formed in a knot is known for almost 30 years.
However, as they are not common, only a fraction of such proteins is available in the Protein …

We describe a framework for interactive molecular dynamics in a multiuser virtual reality
(VR) environment, combining rigorous cloud-mounted atomistic physics simulations with …

The simultaneous synthesis of a molecular nine-crossing composite knot that contains three
trefoil tangles of the same handedness and a 9 7 3 link (a type of cyclic [3] catenane …

Unusual knot-like structures recently discovered in viral exoribonuclease-resistant RNAs
(xrRNAs) prevent digestion by host RNases to create subgenomic RNAs enhancing …

As molecular scientists have made progress in their ability to engineer nanoscale molecular
structure, we face new challenges in our ability to engineer molecular dynamics (MD) and …

Around 6% of protein structures deposited in the PDB are entangled, forming knots,
slipknots, lassos, links, and θ-curves. In each of these cases, the protein backbone weaves …