Synthesis and biological evaluation of benzofuran piperazine derivatives as potential anticancer agents

TJ Schumacher, N Sah, K Palle, J Rumbley… - Bioorganic & Medicinal …, 2023 - Elsevier
This work describes about the synthesis and evaluation of substituted benzofuran
piperazines as potential anticancer agents. The synthesized candidates have been …

Synthesis, Characterization and Biological Evaluation of Novel Benzamidine Derivatives: Newer Antibiotics for Periodontitis Treatment

MA Sa'ad, R Kavitha, S Fuloria, NK Fuloria… - Antibiotics, 2022 - mdpi.com
Periodontal disease (PD) is complex polymicrobial disease which destroys tooth-supporting
tissue. Although various synthetic inhibitors of periodontitis-triggering pathogens have been …

Electron donor-acceptor (EDA)-complex enabled SF5Cl addition on alkenes and alkynes

A Gilbert, M Birepinte, JF Paquin - Journal of Fluorine Chemistry, 2021 - Elsevier
A new method for the addition of SF 5 Cl on unsaturated compounds was developed, based
on the use of an electron donor-acceptor (EDA)-complex and visible light irradiation. The …

Predicting the bioactivity of 2-alkoxycarbonylallyl esters as potential antiproliferative agents against pancreatic cancer (MiaPaCa-2) cell lines: GFA-based QSAR and …

OE Oyeneyin, BS Obadawo, AA Olanrewaju… - Journal of Genetic …, 2021 - Elsevier
Background The number of cancer-related deaths is on the increase, combating this deadly
disease has proved difficult owing to resistance and some serious side effects associated …

Conjugate substitution and addition of α-substituted acrylate: a highly efficient, facile, convenient, and versatile approach to fabricate degradable polymers by dynamic …

Y Kohsaka, T Miyazaki, K Hagiwara - Polymer Chemistry, 2018 - pubs.rsc.org
Polycondensation of bis [α-(halomethyl) acrylate] and dithiols, dicarboxylic acids, primary
monoamines, and bisphenols via conjugate substitution yielded a series of poly (conjugated …

Two‐photon fluorescence lifetime imaging of intrinsic NADH in three‐dimensional tumor models

A Cong, RML Pimenta, HB Lee, V Mereddy… - Cytometry Part …, 2019 - Wiley Online Library
Most studies using intrinsic NAD (P) H as biomarkers for energy metabolism and
mitochondrial anomalies have been conducted in routine two‐dimensional (2D) cell culture …

Synthesis and biological evaluation of novel 2-alkoxycarbonylallylester phosphonium derivatives as potential anticancer agents

ZS Gardner, TJ Schumacher, CT Ronayne… - Bioorganic & Medicinal …, 2021 - Elsevier
Several phosphonium derivatives have been synthesized from Baylis-Hillman (BH) reaction
derived allyl bromides and aryl phosphines as mitochondria targeting anticancer agents. In …

Synthesis and Biological Evaluation of Telmisartan Alkylamine Derivatives as Potential Anticancer Agents

TJ Schumacher, ZS Gardner, MP McParlan… - Anticancer …, 2024 - ar.iiarjournals.org
Background/Aim: Telmisartan is an angiotensin II receptor type 1 (AT1) antagonist with
anticancer properties against solid and hematological cancer cell lines. Using telmisartan as …

Investigation of the Anticancer Potential of 2-alkoxycarbonylallyl Esters Against Metastatic Murine Breast Cancer Line 4T1 Targeting the EGFR: A Combined Molecular …

BS Obadawo, OE Oyeneyin, TO Owolabi… - Letters in Drug …, 2022 - ingentaconnect.com
Background: The search for novel and potent anticancer drugs is imperative. This present
study aims to unravel the mechanisms of action of 2-alkoxyecarbonyl esters using robust …

Associated anisotropy of intrinsic NAD (P) H for monitoring changes in the metabolic activities of breast cancer cells (4T1) in three-dimensional collagen matrix

ATQ Cong, RML Pimenta, J Holy… - Physical Chemistry …, 2021 - pubs.rsc.org
The majority of in vitro studies of living cells are routinely conducted in a two-dimensional
(2D) monolayer culture. Recent studies, however, suggest that 2D cell culture promotes …