The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

Endocrine cells within the pancreatic islets of Langerhans are heterogeneous in terms of
transcriptional profile, protein expression and the regulation of hormone release. Even …

Mice remain the most studied animal model in pancreas research. Since the findings of this
research are typically extrapolated to humans, it is important to understand both similarities …

Pancreatic β cells secrete insulin, the body's only hormone capable of lowering plasma
glucose levels. Impaired or insufficient insulin secretion results in diabetes mellitus. The β …

Glucagon, a hormone secreted from the α-cells of the endocrine pancreas, is critical for
blood glucose homeostasis. It is the major counterpart to insulin and is released during …

Angiogenesis is an important component in the development of thyroid goitre. Vascular
endothelial growth factor (VEGF) represents a family of specific endothelial cell mitogens …

The glucoregulatory hormones insulin and glucagon are released from the β-and α-cells of
the pancreatic islets. In both cell types, secretion is secondary to firing of action potentials …

Abstract Changes in cytosolic free Ca 2+ concentration ([Ca 2+] c) play a crucial role in the
control of insulin secretion from the electrically excitable pancreatic β-cell. Secretion is …

Pancreatic β cell dysfunction is pathognomonic of type 2 diabetes mellitus (T2DM) and is
driven by environmental and genetic factors. β cell responses to glucose and to incretins …

In β cells, stimulation by metabolic, hormonal, neuronal, and pharmacological factors is
coupled to secretion of insulin through different intracellular signaling pathways. Our …