Increasing evidence supports the involvement of DNA damage in several
neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Elevated levels …

Extracellular vesicles (EVs) are small reservoirs of different molecules and important
mediators of cell-to-cell communication. As putative vehicles of misfolded protein …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease mainly
affecting upper and lower motoneurons. Several functionally heterogeneous genes have …

G4C2 hexanucleotide repeat expansions in a non-coding region of the C9orf72 gene are
the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal …

A hexanucleotide repeat expansion (HRE) within the chromosome 9 open reading frame 72
(C9orf72) gene is the most prevalent cause of amyotrophic lateral sclerosis/fronto-temporal …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder and is characterized by
degeneration and axon loss from the upper motor neuron, that descends from the lower …

Hexanucleotide repeat expansions of variable size in C9orf72 are the most prevalent
genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Sense and …

In many types of familial amyotrophic lateral sclerosis (fALS), mutations cause proteins to
gain toxic properties that mediate neurodegenerative processes. It is becoming increasingly …

The hallmark of age-related neurodegenerative diseases is the appearance of cellular
protein deposits and spreading of this pathology throughout the central nervous system …

The disassembly of the neuromuscular junction (NMJ) is an early event in amyotrophic
lateral sclerosis (ALS), ultimately leading to motor dysfunction and lethal respiratory …