Simple Summary The fusion between sperm and oocyte results in a zygote, which is a single
totipotent cell with the ability to develop into a functional organism. Totipotent cells can give …

The preimplantation development of mammals generally follows the same plan. It starts with
the formation of a totipotent zygote, and through consecutive cleavage divisions and …

High-resolution molecular programmes delineating the cellular foundations of mammalian
embryogenesis have emerged recently. Similar analysis of human embryos is limited to pre …

The inner cell mass (ICM) of mammalian blastocysts consists of pluripotent epiblast and
hypoblast lineages, which develop into embryonic and extraembryonic tissues, respectively …

The role of the pluripotency factor NANOG during the second embryonic lineage
differentiation has been studied extensively in mouse, although species-specific differences …

Early mammal embryogenesis starts with oocyte fertilization, giving rise to the zygote. The
events that the newly formed zygote surpasses are crucial to the embryo developmental …

Background This study describes the generation and analysis of the transcriptional profile of
bovine inner cell mass (ICM) and trophectoderm (TE), obtained from in vivo developed …

There have been significant advances in understanding human embryogenesis using
human pluripotent stem cells (hPSCs) in conventional monolayer and 3D self-organized …

Background The segregation of the hypoblast and the emergence of the pluripotent epiblast
mark the final stages of blastocyst formation in mammalian embryos. In bovine embryos the …

Early embryogenesis is characterized by the segregation of cell lineages that fulfill critical
roles in the establishment of pregnancy and development of the fetus. The formation of the …