Tuberculosis (TB) is a serious public health problem worldwide. Its situation is worsened by
the presence of multidrug resistant (MDR) strains of Mycobacterium tuberculosis, the …

Triclabendazole (TCBZ) is the only chemical that kills early immature and adult Fasciola
hepatica (liver fluke) but widespread resistance to the drug greatly compromises fluke …

Within the past 10 years, treatment and diagnostic guidelines for nontuberculous
mycobacteria have been recommended by the American Thoracic Society (ATS) and the …

For the successful treatment of pulmonary tuberculosis, drugs need to penetrate complex
lung lesions and permeate the mycobacterial cell wall in order to reach their intracellular …

Tuberculosis (TB) chemotherapy started in the 1930s with the discovery by Domagk and
colleagues of the anti‐TB activity of sulfonamides. Since these compounds were very toxic …

Drug resistance in tuberculosis (TB) is a particular problem because the lengthy therapy of
at least 6 months makes patient compliance very difficult, which frequently creates drug …

Mycolic acids are very long‐chain fatty acids representing essential components of the
mycobacterial cell wall. Considering their importance, characterization of key enzymes …

The modern age of drug discovery, which had been slowly gathering momentum during the
early part of the twentieth century, exploded into life in the 1940s with the isolation of …

Tuberculosis (TB) claims a life every 10 seconds and global mortality rates are increasing
despite the use of chemotherapy. But why have we not progressed towards the eradication …

Pyrazinamide (PZA) is a critical component of first-and second-line treatments of
tuberculosis (TB), yet its mechanism of action largely remains an enigma. We carried out a …