Role of ROS and RNS sources in physiological and pathological conditions
S Di Meo, TT Reed, P Venditti… - Oxidative medicine and …, 2016 - Wiley Online Library
There is significant evidence that, in living systems, free radicals and other reactive oxygen
and nitrogen species play a double role, because they can cause oxidative damage and …
and nitrogen species play a double role, because they can cause oxidative damage and …
Mitochondria and calcium in Alzheimer's disease: from cell signaling to neuronal cell death
M Calvo-Rodriguez, BJ Bacskai - Trends in neurosciences, 2021 - cell.com
Mitochondrial dysfunction has been implicated in the pathogenesis of almost all
neurological diseases, including Alzheimer's disease (AD). Historically, a primary focus in …
neurological diseases, including Alzheimer's disease (AD). Historically, a primary focus in …
[HTML][HTML] Mitochondrial calcium: effects of its imbalance in disease
D Matuz-Mares, M González-Andrade… - Antioxidants, 2022 - mdpi.com
Calcium is used in many cellular processes and is maintained within the cell as free calcium
at low concentrations (approximately 100 nM), compared with extracellular (millimolar) …
at low concentrations (approximately 100 nM), compared with extracellular (millimolar) …
The road to restoring neural circuits for the treatment of Alzheimer's disease
Alzheimer's disease is a progressive loss of memory and cognition, for which there is no
cure. Although genetic studies initially suggested a primary role for amyloid-in Alzheimer's …
cure. Although genetic studies initially suggested a primary role for amyloid-in Alzheimer's …
Calcium signaling and molecular mechanisms underlying neurodegenerative diseases
Abstract Calcium (Ca 2+) is a ubiquitous second messenger that regulates various activities
in eukaryotic cells. Especially important role calcium plays in excitable cells. Neurons …
in eukaryotic cells. Especially important role calcium plays in excitable cells. Neurons …
[HTML][HTML] Neurodegenerative disorders and gut-brain interactions
Neurodegenerative disorders (NDs) affect essential functions not only in the CNS, but also
cause persistent gut dysfunctions, suggesting that they have an impact on both CNS and gut …
cause persistent gut dysfunctions, suggesting that they have an impact on both CNS and gut …
Impairments of neural circuit function in Alzheimer's disease
MA Busche, A Konnerth - Philosophical Transactions of …, 2016 - royalsocietypublishing.org
An essential feature of Alzheimer's disease (AD) is the accumulation of amyloid-β (Aβ)
peptides in the brain, many years to decades before the onset of overt cognitive symptoms …
peptides in the brain, many years to decades before the onset of overt cognitive symptoms …
Alzheimer's disease
HW Querfurth, FM LaFerla - New England Journal of Medicine, 2010 - Mass Medical Soc
This review of Alzheimer's disease assembles a variety of findings relevant to the
mechanism of the disease and ties them together using the current understanding of the …
mechanism of the disease and ties them together using the current understanding of the …
Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration
The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions
essential for cellular homeostasis, development, and stress responsiveness. In response to …
essential for cellular homeostasis, development, and stress responsiveness. In response to …
[HTML][HTML] Neuronal sigma-1 receptors: signaling functions and protective roles in neurodegenerative diseases
DA Ryskamp, S Korban, V Zhemkov… - Frontiers in …, 2019 - frontiersin.org
Sigma-1 receptor (S1R) is a multi-functional, ligand-operated protein situated in
endoplasmic reticulum (ER) membranes and changes in its function and/or expression have …
endoplasmic reticulum (ER) membranes and changes in its function and/or expression have …