Lipid droplet biogenesis and functions in health and disease
Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …
Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics
In mammals, the white adipocyte is a cell type that is specialized for storage of energy (in the
form of triacylglycerols) and for energy mobilization (as fatty acids). White adipocyte …
form of triacylglycerols) and for energy mobilization (as fatty acids). White adipocyte …
Adipogenesis and metabolic health
AL Ghaben, PE Scherer - Nature reviews Molecular cell biology, 2019 - nature.com
Obesity is characterized by increased adipose tissue mass and has been associated with a
strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public …
strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public …
The diagnosis and management of lipodystrophy syndromes: a multi-society practice guideline
RJ Brown, D Araujo-Vilar, PT Cheung… - The Journal of …, 2016 - academic.oup.com
Objective: Lipodystrophy syndromes are extremely rare disorders of deficient body fat
associated with potentially serious metabolic complications, including diabetes …
associated with potentially serious metabolic complications, including diabetes …
Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity
In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …
cause of numerous health complications and increased mortality. Being a complex and …
Adipose tissue: between the extremes
A Vegiopoulos, M Rohm, S Herzig - The EMBO journal, 2017 - embopress.org
Adipose tissue represents a critical component in healthy energy homeostasis. It fulfills
important roles in whole‐body lipid handling, serves as the body's major energy storage …
important roles in whole‐body lipid handling, serves as the body's major energy storage …
Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference
BA Neuschwander-Tetri, SH Caldwell - Hepatology, 2003 - Elsevier
Fatty liver disease that develops in the absence of alcohol abuse is recognized increasingly
as a major health burden. This report summarizes the presentations and discussions at a …
as a major health burden. This report summarizes the presentations and discussions at a …
Adipose organ development and remodeling
S Cinti - Comprehensive Physiology, 2018 - iris.univpm.it
During the last decades, research on adipose tissues has spread in parallel with the
extension of obesity. Several observations converged on the idea that adipose tissues are …
extension of obesity. Several observations converged on the idea that adipose tissues are …
Lipodystrophies: genetic and acquired body fat disorders
A Garg - The Journal of Clinical Endocrinology & Metabolism, 2011 - academic.oup.com
Context: Lipodystrophies are heterogeneous, genetic or acquired disorders characterized by
selective loss of body fat and predisposition to insulin resistance. The extent of fat loss …
selective loss of body fat and predisposition to insulin resistance. The extent of fat loss …
Update and nomenclature proposal for mammalian lysophospholipid acyltransferases, which create membrane phospholipid diversity
WJ Valentine, K Yanagida, H Kawana, N Kono… - Journal of Biological …, 2022 - ASBMB
The diversity of glycerophospholipid species in cellular membranes is immense and affects
various biological functions. Glycerol-3-phosphate acyltransferases (GPATs) and …
various biological functions. Glycerol-3-phosphate acyltransferases (GPATs) and …