Lipid droplet biogenesis and functions in health and disease

A Zadoorian, X Du, H Yang - Nature Reviews Endocrinology, 2023 - nature.com
Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …

Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics

P Morigny, J Boucher, P Arner, D Langin - Nature Reviews …, 2021 - nature.com
In mammals, the white adipocyte is a cell type that is specialized for storage of energy (in the
form of triacylglycerols) and for energy mobilization (as fatty acids). White adipocyte …

Adipogenesis and metabolic health

AL Ghaben, PE Scherer - Nature reviews Molecular cell biology, 2019 - nature.com
Obesity is characterized by increased adipose tissue mass and has been associated with a
strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public …

The diagnosis and management of lipodystrophy syndromes: a multi-society practice guideline

RJ Brown, D Araujo-Vilar, PT Cheung… - The Journal of …, 2016 - academic.oup.com
Objective: Lipodystrophy syndromes are extremely rare disorders of deficient body fat
associated with potentially serious metabolic complications, including diabetes …

Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity

M Pigeyre, FT Yazdi, Y Kaur, D Meyre - Clinical science, 2016 - portlandpress.com
In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …

Adipose tissue: between the extremes

A Vegiopoulos, M Rohm, S Herzig - The EMBO journal, 2017 - embopress.org
Adipose tissue represents a critical component in healthy energy homeostasis. It fulfills
important roles in whole‐body lipid handling, serves as the body's major energy storage …

Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference

BA Neuschwander-Tetri, SH Caldwell - Hepatology, 2003 - Elsevier
Fatty liver disease that develops in the absence of alcohol abuse is recognized increasingly
as a major health burden. This report summarizes the presentations and discussions at a …

Adipose organ development and remodeling

S Cinti - Comprehensive Physiology, 2018 - iris.univpm.it
During the last decades, research on adipose tissues has spread in parallel with the
extension of obesity. Several observations converged on the idea that adipose tissues are …

Lipodystrophies: genetic and acquired body fat disorders

A Garg - The Journal of Clinical Endocrinology & Metabolism, 2011 - academic.oup.com
Context: Lipodystrophies are heterogeneous, genetic or acquired disorders characterized by
selective loss of body fat and predisposition to insulin resistance. The extent of fat loss …

Update and nomenclature proposal for mammalian lysophospholipid acyltransferases, which create membrane phospholipid diversity

WJ Valentine, K Yanagida, H Kawana, N Kono… - Journal of Biological …, 2022 - ASBMB
The diversity of glycerophospholipid species in cellular membranes is immense and affects
various biological functions. Glycerol-3-phosphate acyltransferases (GPATs) and …