[HTML][HTML] OxMIF: a druggable isoform of macrophage migration inhibitory factor in cancer and inflammatory diseases

M Thiele, SC Donnelly, RA Mitchell - Journal for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine with a pleiotropic
spectrum of biological functions implicated in the pathogenesis of cancer and inflammatory …

Hallmarks of cancer affected by the MIF cytokine family

R Mora Barthelmess, B Stijlemans… - Cancers, 2023 - mdpi.com
Simple Summary The aim of this review is to summarize the available information regarding
the MIF family in cancer, comprising MIF and DDT. Both cytokines are highly expressed in …

[HTML][HTML] Single-cell RNA-seq of a soft-tissue sarcoma model reveals the critical role of tumor-expressed MIF in shaping macrophage heterogeneity

FHG Tessaro, EY Ko, M De Simone, R Piras, MT Broz… - Cell reports, 2022 - cell.com
The standard of care is unsuccessful to treat recurrent and aggressive soft-tissue sarcomas.
Interventions aimed at targeting components of the tumor microenvironment have shown …

Blocking the Self‐Destruct Program of Dopamine Neurons through Macrophage Migration Inhibitory Factor Nuclease Inhibition

J Patel, VL Dawson, TM Dawson - Movement Disorders, 2024 - Wiley Online Library
Parkinson's disease (PD) is a progressive neurodegenerative condition that
pathognomonically involves the death of dopaminergic neurons in the substantia nigra pars …

USP5 promotes breast cancer cell proliferation and metastasis by stabilizing HIF2α

W Huang, X Liu, Y Zhang, M Deng, G Li… - Journal of Cellular …, 2022 - Wiley Online Library
Hypoxia‐inducible factor 2α (HIF2α) plays a pivotal role in breast tumor growth and
metastasis. However, the regulatory mechanisms of HIF2α protein stability remain poorly …

MIF promotes neurodegeneration and cell death via its nuclease activity following traumatic brain injury

Z Ruan, Q Lu, JE Wang, M Zhou, S Liu, H Zhang… - Cellular and Molecular …, 2021 - Springer
Traumatic brain injury (TBI), often induced by sports, car accidents, falls, or other daily
occurrences, is a primary non-genetically related risk factor for the development of …

Allosteric inhibitors of macrophage migration inhibitory factor (MIF) Interfere with Apoptosis-Inducing factor (AIF) Co-Localization to prevent Parthanatos

D Chen, A Osipyan, J Adriana, M Kader… - Journal of Medicinal …, 2023 - ACS Publications
Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine and essential
signaling protein associated with inflammation and cancers. One of the newly described …

UBE3B promotes breast cancer progression by antagonizing HIF-2α degradation

Y Wang, X Liu, M Wang, Y Wang, S Wang, L Jin, M Liu… - Oncogene, 2023 - nature.com
Mutations in E3 ubiquitin ligase UBE3B have been linked to Kaufman Oculocerebrofacial
Syndrome (KOS). Accumulating evidence indicates that UBE3B may play an important role …

Role of MIF1/MIF2/CD74 interactions in bladder cancer

BL Woolbright, G Rajendran, E Abbott… - The Journal of …, 2023 - Wiley Online Library
Macrophage migration inhibitory factor (MIF1) is a pleiotropic cytokine involved in
inflammation and cancer. Genetic knockout of Mif1 in the validated N‐butyl‐N‐(4 …

Decoding meningioma heterogeneity and neoplastic cell—macrophage interaction through single-cell transcriptome profiling across pathological grades

H Fan, L Song, J Fan, J Ma, X Li, J Zhang, J Hu… - Journal of translational …, 2023 - Springer
Background Analyzing meningioma of distinct pathological types at the single-cell level can
provide new and valuable insights into the specific biological mechanisms of each cellular …