[HTML][HTML] OxMIF: a druggable isoform of macrophage migration inhibitory factor in cancer and inflammatory diseases
M Thiele, SC Donnelly, RA Mitchell - Journal for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine with a pleiotropic
spectrum of biological functions implicated in the pathogenesis of cancer and inflammatory …
spectrum of biological functions implicated in the pathogenesis of cancer and inflammatory …
Hallmarks of cancer affected by the MIF cytokine family
R Mora Barthelmess, B Stijlemans… - Cancers, 2023 - mdpi.com
Simple Summary The aim of this review is to summarize the available information regarding
the MIF family in cancer, comprising MIF and DDT. Both cytokines are highly expressed in …
the MIF family in cancer, comprising MIF and DDT. Both cytokines are highly expressed in …
[HTML][HTML] Single-cell RNA-seq of a soft-tissue sarcoma model reveals the critical role of tumor-expressed MIF in shaping macrophage heterogeneity
The standard of care is unsuccessful to treat recurrent and aggressive soft-tissue sarcomas.
Interventions aimed at targeting components of the tumor microenvironment have shown …
Interventions aimed at targeting components of the tumor microenvironment have shown …
Blocking the Self‐Destruct Program of Dopamine Neurons through Macrophage Migration Inhibitory Factor Nuclease Inhibition
Parkinson's disease (PD) is a progressive neurodegenerative condition that
pathognomonically involves the death of dopaminergic neurons in the substantia nigra pars …
pathognomonically involves the death of dopaminergic neurons in the substantia nigra pars …
USP5 promotes breast cancer cell proliferation and metastasis by stabilizing HIF2α
W Huang, X Liu, Y Zhang, M Deng, G Li… - Journal of Cellular …, 2022 - Wiley Online Library
Hypoxia‐inducible factor 2α (HIF2α) plays a pivotal role in breast tumor growth and
metastasis. However, the regulatory mechanisms of HIF2α protein stability remain poorly …
metastasis. However, the regulatory mechanisms of HIF2α protein stability remain poorly …
MIF promotes neurodegeneration and cell death via its nuclease activity following traumatic brain injury
Traumatic brain injury (TBI), often induced by sports, car accidents, falls, or other daily
occurrences, is a primary non-genetically related risk factor for the development of …
occurrences, is a primary non-genetically related risk factor for the development of …
Allosteric inhibitors of macrophage migration inhibitory factor (MIF) Interfere with Apoptosis-Inducing factor (AIF) Co-Localization to prevent Parthanatos
Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine and essential
signaling protein associated with inflammation and cancers. One of the newly described …
signaling protein associated with inflammation and cancers. One of the newly described …
UBE3B promotes breast cancer progression by antagonizing HIF-2α degradation
Y Wang, X Liu, M Wang, Y Wang, S Wang, L Jin, M Liu… - Oncogene, 2023 - nature.com
Mutations in E3 ubiquitin ligase UBE3B have been linked to Kaufman Oculocerebrofacial
Syndrome (KOS). Accumulating evidence indicates that UBE3B may play an important role …
Syndrome (KOS). Accumulating evidence indicates that UBE3B may play an important role …
Role of MIF1/MIF2/CD74 interactions in bladder cancer
BL Woolbright, G Rajendran, E Abbott… - The Journal of …, 2023 - Wiley Online Library
Macrophage migration inhibitory factor (MIF1) is a pleiotropic cytokine involved in
inflammation and cancer. Genetic knockout of Mif1 in the validated N‐butyl‐N‐(4 …
inflammation and cancer. Genetic knockout of Mif1 in the validated N‐butyl‐N‐(4 …
Decoding meningioma heterogeneity and neoplastic cell—macrophage interaction through single-cell transcriptome profiling across pathological grades
Background Analyzing meningioma of distinct pathological types at the single-cell level can
provide new and valuable insights into the specific biological mechanisms of each cellular …
provide new and valuable insights into the specific biological mechanisms of each cellular …