Vibrio cholerae is the causative agent of cholera, a highly contagious diarrheal disease
affecting millions worldwide each year. Cholera is a major public health problem, primarily in …

Sepsis is the leading killer of children worldwide, but this is not reflected in estimates of
global mortality. While it is important to classify deaths according to specific causes such as …

Sporotrichosis associated with zoonotic transmission remains a relevant public health
problem in Rio de Janeiro, Brazil, affecting a large at-risk population, which includes HIV …

Background Mucosal Associated Invariant T (MAIT) cells are innate-like T cells found in
abundance in the intestinal mucosa, and are thought to play a role in bridging the innate …

Background Vibrio cholerae is the cause of cholera, a severe watery diarrhea. Protection
against cholera is serogroup specific. Serogroup specificity is defined by the O-specific …

Oral cholera vaccination is used to induce immune responses in the intestines to protect
against cholera infection. However, oral vaccination may also affect immune responses in …

Toxic shock syndrome (TSS) is capable of inducing life-threatening fever, rash, and systemic
organ failure, though the specific mechanisms behind these symptoms remain poorly …

Epitope-based vaccines permit the selection of only a specific subset of epitopes to induce
the necessary immune response, thus providing a rational alternative to conventional design …

Mathematical modeling can be a valuable tool for studying infectious disease outbreak
dynamics and simulating the effects of possible interventions. Here, we describe …

Background Studies of the immunogenicity of the killed bivalent whole cell oral cholera
vaccine, Shanchol, have been performed in historically cholera-endemic areas of Asia …