Tight junctions (TJs) regulate the passage of ions and molecules through the paracellular
pathway in epithelial and endothelial cells. TJs are highly dynamic structures whose degree …

The tight junction is an intracellular junctional structure that mediates adhesion between
epithelial cells and is required for epithelial cell function. Tight junctions control paracellular …

Ten years ago, par-1 and par-3 were cloned as two of the six par genes essential for the
asymmetric division of the Caenorhabditis elegans zygote. PAR-1 is a protein kinase …

PAR-1 kinases are required for polarity in diverse cell types, such as epithelial cells, where
they localize laterally. PAR-1 activity is believed to be transduced by binding of 14-3-3 …

The anterior–posterior axis of Drosophila is established before fertilisation when the oocyte
becomes polarised to direct the localisation of bicoid and oskar mRNAs to opposite poles of …

Gametes are highly specialized cell types produced by a complex differentiation process.
Production of viable oocytes requires a series of precise and coordinated molecular events …

Par6 and atypical protein kinase C are key players in the establishment of cell polarity. First
discovered in Caenorhabditis elegans, the function of this protein complex is conserved in …

Background: Recent studies have revealed that aPKC (atypical protein kinase C), PAR‐3
and PAR‐6 play indispensable roles in the regulation of various cell polarization events …

The orthogonal axes of Drosophila are established during oogenesis through a hierarchical
series of symmetry-breaking steps, most of which can be traced back to asymmetries …

The transmembrane protein Dystroglycan is a central element of the dystrophin-associated
glycoprotein complex, which is involved in the pathogenesis of many forms of muscular …