von Hippel-Lindau (VHL) disease is a rare hereditary cancer syndrome that causes a
predisposition to renal clear-cell carcinoma, hemangioblastoma, pheochromocytoma, and …

E3 ubiquitin ligases are key enzymes within the ubiquitin proteasome system which catalyze
the ubiquitination of proteins, targeting them for proteasomal degradation. E3 ligases are …

Intrinsically disordered proteins and regions (IDPs and IDRs) and their importance in biology
are becoming increasingly recognized in biology, biochemistry, molecular biology and …

Inactivation of the tumor suppressor von Hippel–Lindau (VHL) gene is a key event in
hereditary and sporadic clear cell renal cell carcinomas (ccRCC). The mechanistic target of …

Von Hippel-Lindau (VHL) syndrome is characterized by hemangioblastomas of the brain,
spinal cord, and retina; renal cysts and clear cell renal cell carcinoma; pheochromocytoma …

Von Hippel-Lindau disease (VHL disease or VHL syndrome) is a familial multisystem
neoplastic syndrome stemming from germline disease-associated variants of the VHL tumor …

Our understanding of gene expression has come far since the 'one-gene one-polypeptide'
hypothesis proposed by Beadle and Tatum. In this review, we address the gradual …

Abstract Mutations in von Hippel-Lindau tumor suppressor protein (pVHL) predispose to
develop tumors affecting specific target organs, such as the retina, epididymis, adrenal …

Breeding vegetative crops (eg beets, cabbage, forage grasses) is challenged by two
conflicting aims. For field production, flowering must be avoided while flowering and seed …

Familiar cancers represent a privileged point of view for studying the complex cellular events
inducing tumor transformation. Von Hippel-Lindau syndrome, a familiar predisposition to …