Quantitative magnetic resonance imaging of brain anatomy and in vivo histology

N Weiskopf, LJ Edwards, G Helms… - Nature Reviews …, 2021 - nature.com
Quantitative magnetic resonance imaging (qMRI) goes beyond conventional MRI, which
aims primarily at local image contrast. It provides specific physical parameters related to the …

[HTML][HTML] Cerebral white matter myelination and relations to age, gender, and cognition: a selective review

IS Buyanova, M Arsalidou - Frontiers in human neuroscience, 2021 - frontiersin.org
White matter makes up about fifty percent of the human brain. Maturation of white matter
accompanies biological development and undergoes the most dramatic changes during …

[HTML][HTML] hMRI–A toolbox for quantitative MRI in neuroscience and clinical research

K Tabelow, E Balteau, J Ashburner, MF Callaghan… - Neuroimage, 2019 - Elsevier
Neuroscience and clinical researchers are increasingly interested in quantitative magnetic
resonance imaging (qMRI) due to its sensitivity to micro-structural properties of brain tissue …

[HTML][HTML] Myelin quantification with MRI: A systematic review of accuracy and reproducibility

CWJ van der Weijden, DV García, RJH Borra… - Neuroimage, 2021 - Elsevier
Objectives Currently, multiple sclerosis is treated with anti-inflammatory therapies, but these
treatments lack efficacy in progressive disease. New treatment strategies aim to repair …

[HTML][HTML] Microstructural imaging of human neocortex in vivo

LJ Edwards, E Kirilina, S Mohammadi, N Weiskopf - Neuroimage, 2018 - Elsevier
The neocortex of the human brain is the seat of higher brain function. Modern imaging
techniques, chief among them magnetic resonance imaging (MRI), allow non-invasive …

Quantitative myelin imaging with MRI and PET: an overview of techniques and their validation status

CWJ van der Weijden, E Biondetti, IW Gutmann… - Brain, 2023 - academic.oup.com
Myelin is the protective sheath wrapped around axons, consisting of a phospholipid bilayer
with water between the wraps. The measurement of damage to the myelin sheaths, the …

Multiparameter mapping of relaxation (R1, R2*), proton density and magnetization transfer saturation at 3 T: A multicenter dual‐vendor reproducibility and repeatability …

T Leutritz, M Seif, G Helms, RS Samson… - Human brain …, 2020 - Wiley Online Library
Multicenter clinical and quantitative magnetic resonance imaging (qMRI) studies require a
high degree of reproducibility across different sites and scanner manufacturers, as well as …

[HTML][HTML] Overview of myelin, major myelin lipids, and myelin-associated proteins

A Kister, I Kister - Frontiers in Chemistry, 2023 - frontiersin.org
Myelin is a modified cell membrane that forms a multilayer sheath around the axon. It retains
the main characteristics of biological membranes, such as lipid bilayer, but differs from them …

[HTML][HTML] Estimating axon conduction velocity in vivo from microstructural MRI

M Drakesmith, R Harms, SU Rudrapatna, GD Parker… - Neuroimage, 2019 - Elsevier
The conduction velocity (CV) of action potentials along axons is a key neurophysiological
property central to neural communication. The ability to estimate CV in humans in vivo from …

[HTML][HTML] Towards in vivo g-ratio mapping using MRI: Unifying myelin and diffusion imaging

S Mohammadi, MF Callaghan - Journal of neuroscience methods, 2021 - Elsevier
Background The g-ratio, quantifying the comparative thickness of the myelin sheath
encasing an axon, is a geometrical invariant that has high functional relevance because of …