Resident tissue macrophages (RTMs) have a broad spectrum of immune-and non-immune-
related tissue-supporting activities. The roots of this heterogeneity and versatility are only …

Chronic venous disease (CVD) is a multifactorial condition affecting an important
percentage of the global population. It ranges from mild clinical signs, such as …

Fibroblastic stromal cells are as diverse, in origin and function, as the niches they fashion in
the mammalian body. This cellular variety impacts the spectrum of responses elicited by the …

Blood production depends on rare haematopoietic stem cells (HSCs) and haematopoietic
stem and progenitor cells (HSPCs) that ultimately take up residence in the bone marrow …

Hematopoiesis is the process by which both fetal and adult organisms derive the full
repertoire of blood cells from a single multipotent progenitor cell type, the hematopoietic …

Myelofibrosis (MF) is a disease associated with high unmet medical needs because
allogeneic stem cell transplantation is not an option for most patients, and JAK inhibitors are …

Hematopoietic stem cells (HSCs) are fundamental to the generation of the body's blood and
immune cells. They reside primarily within the bone marrow (BM) niche microenvironment …

Hypertrophic chondrocytes give rise to osteoblasts during skeletal development; however,
the process by which these non-mitotic cells make this transition is not well understood. Prior …

Pulmonary mesenchymal cells are critical players in both the mouse and human during lung
development and disease states. They are increasingly recognized as highly …

Remote tumors disrupt the bone marrow (BM) ecosystem (BME), eliciting the overproduction
of BM-derived immunosuppressive cells. However, the underlying mechanisms remain …