Patient and disease–specific induced pluripotent stem cells for discovery of personalized cardiovascular drugs and therapeutics
Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …
Cellular and engineered organoids for cardiovascular models
An ensemble of in vitro cardiac tissue models has been developed over the past several
decades to aid our understanding of complex cardiovascular disorders using a reductionist …
decades to aid our understanding of complex cardiovascular disorders using a reductionist …
Use of human induced pluripotent stem cell–derived cardiomyocytes in preclinical cancer drug cardiotoxicity testing: a scientific statement from the American Heart …
It is now well recognized that many lifesaving oncology drugs may adversely affect the heart
and cardiovascular system, including causing irreversible cardiac injury that can result in …
and cardiovascular system, including causing irreversible cardiac injury that can result in …
Metabolic aspects of anthracycline cardiotoxicity
M Russo, A Della Sala, CG Tocchetti… - … treatment options in …, 2021 - Springer
Opinion statement Heart failure (HF) is increasingly recognized as the major complication of
chemotherapy regimens. Despite the development of modern targeted therapies such as …
chemotherapy regimens. Despite the development of modern targeted therapies such as …
Revolutionizing disease modeling: the emergence of organoids in cellular systems
R Silva-Pedrosa, AJ Salgado, PE Ferreira - Cells, 2023 - mdpi.com
Cellular models have created opportunities to explore the characteristics of human diseases
through well-established protocols, while avoiding the ethical restrictions associated with …
through well-established protocols, while avoiding the ethical restrictions associated with …
Generation and maturation of human iPSC-derived 3D organotypic cardiac microtissues in long-term culture
Cardiovascular diseases remain the leading cause of death worldwide; hence there is an
increasing focus on developing physiologically relevant in vitro cardiovascular tissue …
increasing focus on developing physiologically relevant in vitro cardiovascular tissue …
Stem cells for next level toxicity testing in the 21st century
E Fritsche, T Haarmann‐Stemmann, J Kapr, S Galanjuk… - Small, 2021 - Wiley Online Library
The call for a paradigm change in toxicology from the United States National Research
Council in 2007 initiates awareness for the invention and use of human‐relevant alternative …
Council in 2007 initiates awareness for the invention and use of human‐relevant alternative …
Modeling cardiovascular diseases with hiPSC-derived cardiomyocytes in 2D and 3D cultures
C Sacchetto, L Vitiello, LJ de Windt… - International journal of …, 2020 - mdpi.com
In the last decade, the generation of cardiac disease models based on human-induced
pluripotent stem cells (hiPSCs) has become of common use, providing new opportunities to …
pluripotent stem cells (hiPSCs) has become of common use, providing new opportunities to …
Modeling cardiac disease mechanisms using induced pluripotent stem cell-derived cardiomyocytes: progress, promises and challenges
Cardiovascular diseases (CVDs) are a class of disorders affecting the heart or blood
vessels. Despite progress in clinical research and therapy, CVDs still represent the leading …
vessels. Despite progress in clinical research and therapy, CVDs still represent the leading …
Modeling hypertrophic cardiomyopathy with human cardiomyocytes derived from induced pluripotent stem cells
J Li, X Feng, X Wei - Stem Cell Research & Therapy, 2022 - Springer
One of the obstacles in studying the pathogenesis of hypertrophic cardiomyopathy (HCM) is
the poor availability of myocardial tissue samples at the early stages of disease …
the poor availability of myocardial tissue samples at the early stages of disease …