Basal forebrain cholinergic signalling: development, connectivity and roles in cognition

MR Ananth, P Rajebhosale, R Kim… - Nature Reviews …, 2023 - nature.com
Acetylcholine plays an essential role in fundamental aspects of cognition. Studies that have
mapped the activity and functional connectivity of cholinergic neurons have shown that the …

A multiple hits hypothesis for memory dysfunction in Parkinson disease

S Citro, GD Lazzaro, AT Cimmino, GM Giuffrè… - Nature Reviews …, 2024 - nature.com
Cognitive disorders are increasingly recognized in Parkinson disease (PD), even in early
disease stages, and memory is one of the most affected cognitive domains. Classically …

Cerebral activity manipulation of low-frequency repetitive transcranial magnetic stimulation in post-stroke patients with cognitive impairment

B Yingli, G Zunke, C Wei, W Shiyan - Frontiers in Neurology, 2022 - frontiersin.org
Objective The aim of this study was to evaluate the therapeutic effect of low-frequency
repetitive transcranial magnetic stimulation (rTMS) on post-stroke cognitive impairment …

M1/M4-Preferring Muscarinic Cholinergic Receptor Agonist Xanomeline Reverses Wake and Arousal Deficits in Nonpathologically Aged Mice

JK Russell, SM Ingram, LB Teal… - ACS Chemical …, 2023 - ACS Publications
Degeneration of the cholinergic basal forebrain is implicated in the development of cognitive
deficits and sleep/wake architecture disturbances in mild cognitive impairment (MCI) and …

[HTML][HTML] Longitudinal trajectories of basal forebrain volume in normal aging and Alzheimer's disease

Y Xia, P Maruff, V Doré, P Bourgeat, SM Laws… - Neurobiology of …, 2023 - Elsevier
Dysfunction of the cholinergic basal forebrain (BF) system and amyloid-β (Aβ) deposition are
early pathological features in Alzheimer's disease (AD). However, their association in early …

Parkinson's disease cerebrovascular reactivity pattern: A feasibility study

HJ van der Horn, AA Vakhtin, K Julio… - Journal of Cerebral …, 2024 - journals.sagepub.com
A mounting body of research points to cerebrovascular dysfunction as a fundamental
element in the pathophysiology of Parkinson's disease (PD). In the current feasibility study …

Abnormal Cerebrovascular Activity, Perfusion, and Glymphatic Clearance in Lewy Body Diseases

SG Ryman, AA Vakhtin, AR Mayer… - Movement …, 2024 - Wiley Online Library
Cerebrovascular activity is not only crucial to optimal cerebral perfusion, but also plays an
important role in the glymphatic clearance of interstitial waste, including α‐synuclein. This …

Pharmaceutical and pharmacological studies of Shen Ma Yi Zhi granule for prevention of vascular dementia: A review

S Chang, J Liu, H Li, M Liu, D Shi, L Zhou - Frontiers in Neuroscience, 2022 - frontiersin.org
Background: With dementia significantly increasing hospitalization and disability rates,
worldwide aging of the population presents major challenges to public health. The majority …

Sex‐dependent cholinergic effects on amyloid pathology: A translational study

L German‐Castelan, HRC Shanks, R Gros… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION About two‐thirds of Alzheimer's Disease (AD) patients are women, who
exhibit more severe pathology and cognitive decline than men. Whether biological sex …

Cortical amyloid burden relates to basal forebrain volume in subjective cognitive decline

M Daamen, L Scheef, S Li, MJ Grothe… - Journal of …, 2023 - journals.sagepub.com
Background: Atrophy of cholinergic basal forebrain (BF) nuclei is a frequent finding in
magnetic resonance imaging (MRI) volumetry studies that examined patients with prodromal …