The ATP‐binding cassette (ABC) transporter superfamily is one of the largest membrane
protein families existing in wide spectrum of organisms from prokaryotes to human. ABC …

Multidrug transporter proteins are best known for their contributions to chemoresistance
through the efflux of anticancer drugs from cancer cells. However, a considerable body of …

The multidrug resistance protein 1 (MRP1) encoded by ABCC1 was originally discovered as
a cause of multidrug resistance in tumor cells. However, it is now clear that MRP1 serves a …

Transporters influence the disposition of chemicals within the body by participating in
absorption, distribution, and elimination. Transporters of the solute carrier family (SLC) …

Increases in the intracellular levels of reactive oxygen species (ROS), frequently referred to
as oxidative stress, respresents a potentially toxic insult which if not counteracted will lead to …

Resistance to chemotherapy remains one of the most significant obstacles to successful
cancer treatment. While inhibiting drug efflux mediated by ATP-binding cassette (ABC) …

Multidrug Resistance Proteins (MRPs), together with the cystic fibrosis conductance
regulator (CFTR/ABCC7) and the sulfonylurea receptors (SUR1/ABCC8 and SUR2/ABCC9) …

Prostaglandins are involved in a wide variety of physiological and pathophysiological
processes, but the mechanism of prostaglandin release from cells is not completely …

The nine multidrug resistance proteins (MRPs) represent the major part of the 12 members
of the MRP/CFTR subfamily belonging to the 48 human ATP-binding cassette (ABC) …

The cyclopentenone prostaglandins PGA2, PGA1, and PGJ2 are formed by dehydration
within the cyclopentane ring of PGE2, PGE1, and PGD2. PGJ2 is metabolized further to yield …